Bone Research Society Bone Research Society
 
 

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Osteoporotic Bone

Low power scanning electron microscope image, showing osteoporotic architecture in the fourth lumbar vertebra of an 89 year old woman (x20). The bone is heavily eroded in places by the action of osteoclasts and consists mainly of thin, fragile struts. By kind permission of Alan Boyde

Normal Bone

Low power scanning electron microscope images, showing normal bone architecture in the third lumbar vertebra of a 30 year old woman (x20).  Strong, interconnected plates of bone are visible. By kind permission of Alan Boyde

Normal Bone

Very low power scanning electron microscope image, showing normal bone architecture in the fourth lumbar vertebra of an 41 year year old man (x8). A regular pattern of interconnected plates and thick struts of bone can be seen. By kind permission of Alan Boyde

Osteoclast

Scanning electron micrograph showing osteoclast resorbing bone. By kind permission of Tim Arnett

Osteoclast

Breakfast, lunch and dinner for an osteoclast! By kind permission of Alan Boyde

Osteocytes - Human Bone

Osteocytes - Human bone. By kind permission of Tim Arnett

Osteocytes - Human Bone Osteon Relief

Osteocytes - Human bone, osteon relief. By kind permission of Tim Arnett

Tooth Eruption

Eruption of adult tooth, cat jaw. H & E stained preparation. Field view 1.5 mm. By kind permission of Tim Arnett

Human osteoclast & resorption trails #1

Human osteoclast & resorption trails #1. By kind permission of Tim Arnett

Human osteoclast & resorption trails #2

Human osteoclast & resorption trails #2. By kind permission of Tim Arnett

Human osteoclast & resorption trails #3

Human osteoclast & resorption trails #3. By kind permission of Tim Arnett

Normal Bone

Image of normal bone architecture in the 3rd lumbar vertebra of a 30 year old woman. By kind permission of Tim Arnett.

Osteoporotic Bone

Architecture in the 3rd lumbar vertebra of a 71 year old woman. Note trabecular bone element eroded by osteoclasts. By kind permission of Tim Arnett.

Osteoporotic Bone

Architecture in the 3rd lumbar vertebra of a 71 year old woman. Note trabecular bone element perforated by osteoclasts. By kind permission of Tim Arnett.

Human bone marrow stromal cells

Human bone marrow stromal cells spreading on trabecular bone. By kind permission of Bram Sengers and Richard Oreffo

Human bone marrow stromal cells

Human bone marrow stromal cells spreading on trabecular bone. By kind permission of Bram Sengers and Richard Oreffo

Osteoporotic bone architecture

Low-power scanning electron micrograph of osteoporotic bone architecture in the 3rd lumbar vertebra of a 71 yr old woman. Marrow and other cells have been removed removed to reveal eroded bone elements. Field width = 1.4 mm. By kind permission of Tim Arnett.

Osteoporotic bone architecture

Low-power image of osteoporitic bone architecture. By kind permission of Tim Arnett.

Comparison of normal and osteoporotic bone architecture

(3rd lumbar vertebrae) Marrow and other cells have been removed. Extensive pitting caused by osteoclasts in the osteoporotic bone (RHS) © Tim Arnett, University College London (t.arnett@ucl.ac.uk) High Resolution Version
See also osteoporosis teaching slides

Section of ichthyosaur vertebrae and ribs

Section of ichthyosaur vertebrae and ribs in pyrite nodule. Seatown, Dorset, UK (190 myr). Trabecular bone structure is particularly well preserved in ribs. © Tim Arnett, University College London (t.arnett@ucl.ac.uk) High Resolution Version

Normal human vertebral bone structure

Normal human vertebral bone structure © Tim Arnett, University College London (t.arnett@ucl.ac.uk) High Resolution Version

Scanning Electron Microscopy of osteoporotic bone

Scanning Electron Microscopy of osteoporotic bone (1) © Tim Arnett, University College London (t.arnett@ucl.ac.uk) High Resolution Version

Scanning Electron Microscopy of osteoporotic bone

Scanning Electron Microscopy of osteoporotic bone (2) © Tim Arnett, University College London (t.arnett@ucl.ac.uk) High Resolution Version

Alternatively click on the thumbnails below to load the image:

   
 
             
             

 

These images are freely available for use by non-profit, educational organisations on the understanding that a clear acknowledgement is made.

Commercial organisations wishing to use this (or similar) material should first contact the named researcher.

   
  Normal Bone  

Normal bone architecture in the 4th lumbar vertebra of a 30 year old female

High Resolution GIF (.gif 5.4MB)

(NB. very high resolution gif files - can be magnified to full screen size for viewing)

Courtesy of Alan Boyde (a.boyde@qmul.ac.uk)

       
  Osteoporitic Bone  

Osteoporotic bone architecture in the 4th lumbar vertebra of an 89 year old female

High Resolution GIF - Movie 1 (.gif 5.6MB)
High Resolution GIF - Movie 2 (.gif 4.6MB)

(NB. very high resolution gif files - can be magnified to full screen size for viewing)

Courtesy of Alan Boyde (a.boyde@qmul.ac.uk)

       
 

 

 

Osteoclast

  Movie  

Time lapse movie of a rat osteoclast. This large cell has 7 nuclei, and displays complex motile activity. The sequence is speeded up 100 times

Windows Media Player
Low Resolution (.wmv 3MB)
High Resolution (.wmv 10MB)

Quicktime Player
Low Resolution (.mov 5MB)
High Resolution (.mov 9MB)

By kind permission of Tim Arnett (t.arnett@ucl.ac.uk)
       
 

 

 

Osteoblasts

  Rat osteoblasts  

Time lapse movie of rat osteoblasts. This dense field shows several hundred cells, including a few undergoing mitosis. Note that many osteoblasts display large, waving processes, resembling cilia. The sequence is speeded up 200 times.

Windows Media Player
Low Resolution (.wmv 2MB)
High Resolution (.wmv 10MB)

Quicktime Player
Low Resolution (.mov 4MB)
High Resolution (.mov 6MB)


By kind permission of Isabel Orriss (i.orriss@ucl.ac.uk).
 
   
   

 

  Bone composition  

Bone composition

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Adult human bone sequence   Adult human bone sequence

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Adult human bone sequence osteocytes  

Adult human bone sequence osteocytes

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Tooth eruption & bone cells  

Tooth eruption & bone cells

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Normal to osteoporotic SEM sequence 1 RGB  

Normal to osteoporotic SEM sequence 1 RGB

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Normal to osteoporotic SEM sequence 2 RGB  

Normal to osteoporotic SEM sequence 2 RGB

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Normal Bone  

Normal osteoporotic animations

By kind permission of Prof Alan Boyde (a.boyde@qmul.ac.uk)

  Human osteoclast resorption trails  

Human osteoclast resorption trails

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Osteoclast motility animation  

Osteoclast motility animation

Press right arrow key to activate animation in slide 2

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Ichthyosaur vertebra  

Ichthyosaur vertebra

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Small dinosaur tail vertebra  

Small dinosaur tail vertebra

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Ichthyosaur bone sequence  

Ichthyosaur bone sequence

By kind permission of Prof Tim Arnett (t.arnett@ucl.ac.uk)

  Iguanodon - fossil bone  

Iguanodon - fossil bone
(PDF 411K)

By kind permission of Tim Skerry & John Currey (t.skerry@sheffield.ac.uk)

 

If you would like to contribute an image please email Prof Tim Arnett