Wednesday 26 June

08.30

ORAL COMMUNICATIONS 4: OSTEOBLASTS AND BONE FORMATION
Chairman: Graham Embery

08.30

OC16

ADENOVIRAL BMP-2 GENE TRANSFER IN MESENCHYMAL STEM CELLS - IN VITRO AND IN VIVO BONE FORMATION ON BIODEGRADABLE POLYMER SCAFFOLDS
K A Partridge, X Yang, N M P Clarke, Y Okubo, K Bessho, S M Howdle, K M Shakesheff, R O C Oreffo

08.42

OC17

IDENTIFICATION AND CHARACTERISATION OF PRESENILINS IN OSTEOBLASTS AND THEIR ROLE IN THE CANONICAL WNT SIGNALLING PATHWAY
G J Spencer, E F Shead, M Porter, T S Grewal, P G Genever

08.54

OC18

AMPA TYPE GLUTAMATE RECEPTORS REGULATE OSTEOBLAST/ ADIPOCYTE PLASTICITY AND BONE FORMATION
A F Taylor, S O Odoi, C J Nokes, T M Skerry

09.06

OC19

IDENTIFICATION OF CBFA1-EXPRESSING OSTEOPROGENITOR CELLS BY FLOW CYTOMETRY
K Stewart, K E McDougall, T Whitworth, J N Beresford, J H Tobias, M J Perry

09.18

OC20

EFFECTS OF LEPTIN ON NUMBER AND APOPTOSIS OF OSTEOBLASTS, AND CONTROL OF LEPTIN PRODUCTION BY GLUCOCORTICOIDS
N A Perez, C Elford, J W Gregory, B A J Evans
        

09.30

PLENARY LECTURE
Chairman: Bronwen Evans

IS11

THE CONTROL OF BONE MASS AND REMODELLING BY LEPTIN
Gerard Karsenty
Houston TX, USA
   

10.30

Coffee
  

11.00

POSTER DISCUSSION SESSION
Chairmen: Agi Grigoriadis/Jon Tobias

11:00

P1

FROM RECEPTOR ACTIVATION TO GENE TRASCRIPTION: FUNCTIONAL WNT SIGNALLING IN OSTEOBLASTS
G J Spencer, S L Etheridge, P G Genever

11:05

P2

11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVITY DETERMINES THE EFFECTS OF GLUCOCORTICOIDS ON BONE
M S Cooper, A Blumsohn, P E Goddard, W A Bartlett, R Eastell, M Hewison, P M Stewart

11:10

P3

OSTEOBLAST-STIMULATING FACTOR-1 ENHANCES OSTEOGENIC DIFFERENTIATION OF BONE MARROW STROMAL CELLS, BUT IS NOT OSTEOINDUCTIVE
R S Tare, K A Partridge, X B Yang, N M P Clarke, R O C Oreffo, H I Roach

11:15

P4

ESTIMATES OF NET ENDOGENOUS ACID PRODUCTION (NEAP) ARE ASSOCIATED WITH INCREASED BONE TURNOVER IN EARLY POSTMENOPAUSAL WOMEN: FINDINGS FROM APOSS LONGITUDINAL STUDY
H M Macdonald, S A New, W D Fraser, D M Reid

11:20

P5

PATTERNS OF EXPRESSION OF CHEMOKINES AND THEIR RECEPTORS IN OSTEOCLASTS
J M Lean, C Murphy, K Fuller, T J Chambers

11:25

P6

INTERACTIONS BETWEEN ESTROGEN AND GLUTAMATE  SIGNALLING PATHWAYS
S O Odoi, A F Taylor, K Lee, L E Lanyon, T M Skerry

11:30

P7

THE OESTROGEN RECEPTOR ACTIVATES BMP-6 IN A NON-LIGAND-DEPENDENT MANNER
S M Colley, D B Ong, S Kitazawa, M Norman, D Wynick, J T Tobias

11:35

P8

EFFECT OF OESTROGEN ON BONE TURNOVER IN CORTICAL BONE IN POSTMENOPAUSAL WOMEN
S Vedi, D W Purdie, N J Garrahan, J E Compston

11:40

P9

SPECIFIC IMMUNOLOCALISATION OF A NOVEL PHOSPHATASE TO OSTEOBLASTS AND MINERALISING GROWTH PLATE CHONDROCYTES OF IMMATURE LONG BONES
C Farquharson, E Seawright, B Houston

11:45

P10

LONGITUDINAL CHANGES IN BONE MINERAL DENSITY AND TURNOVER IN NORMAL PREGNANCY
D Hosking, M Kaur, D Pearson, I Godber, N Lawson, P Baker

11:50

P11

3D MICRO-COMPUTED TOMOGRAPHY (MICRO-CT) OF TRABECULAR BONE FROM GROWTH HORMONE DEFICIENT TRANSGENIC RATS
B A J Evans, A Laib, J T Warner, C Elford, S L Evans, J W Gregory, T Wells

11:55

P12

OSTEONAL MATERIAL PROPERTIES IN THE FRACTURED FEMORAL NECK
E L Follon, N Loveridge, D Stokes, W Bonfield
     

12.00

SYMPOSIUM: GROWTH HORMONE AND BONE
Chairmen: Barbara Mawer/Peter Selby

12.00

IS12

GROWTH HORMONE - PHYSIOLOGICAL ASPECTS AND SIGNALLING MECHANISMS
Peter Clayton, Manchester

12.20

IS13

BONE MARROW ADIPOCYTES: A NEGLECTED TARGET TISSUE FOR
GROWTH HORMONE ACTION
Evelien Gevers, London

12.40

IS14

GROWTH HORMONE MODULATION OF BONE METABOLISM AND MINERALISATION- CLINICAL IMPLICATIONS IN HYPOPITUITARISM
Paul Carroll, London
    

13.00
   

Lunch
   

14.00
 
   

ORAL COMMUNICATIONS 5: OSTEOCLAST GENERATION IN HEALTH AND DISEASE
Chairman: Alan Boyde

14.00

OC21

ZOLEDRONIC ACID PREVENTS THE DEVELOPMENT OF MYELOMA BONE DISEASE AND INCREASES SURVIVAL
C M Shipman, K Vanderkerken, H De Raeve, M Perry, A Hijzen, J Lippitt, J Green, E Van Marck, B Van Camp, P I Croucher

14.12

  

OC22
  

EFFECT OF PAMIDRONATE ON PERIPROSTHETIC BONE TURNOVER AND IMPLANT STABILITY AFTER TOTAL HIP ARTHOPLASTY
J M Wilkinson, I Stockley, A J Hamer, R Eastell

14.24

OC23

RANKL-INDEPENDENT INDUCTION OF HUMAN OSTEOCLAST FORMATION AND BONE RESORPTION BY TGF-BETA
I Itonaga, A Sabokbar, O Kudo, L Danks, N A Athanasou

OC24

14.36

POSSIBLE ROLE FOR TGF-BETA-INDUCED SOCS EXPRESSION IN OSTEOCLAST/MACROPHAGE LINEAGE COMMITMENT IN-VITRO
S W Fox, T J Chambers

14.48

OC25

MULTILINEAGE POTENTIAL OF CD34-NEGATIVE UMBILICAL CORD BLOOD CELLS
S J Murant, E L Hutson, C Allen, I S Hitchcock, P G Genever
   

15.00
 

Bone and Tooth Society AGM
  

15.45
 

Prize giving
 

16.00

Close of Meeting