Friday 11 July

08:45

IS11 Genetic control of bone remodeling: insights from rare diseases:

Michael Whyte (St Louis MO, USA)

Chair: Raj Thakker (Oxford, UK)

09:30

Oral Communications

Chairs: Tim Skerry (London, UK)/Graham Williams (London, UK)

09:30

OC16 PLEIOTROPHIN - A NEW INHIBITOR OF BMP-MEDIATED OSTEOINDUCTION: POSSIBLE RELEVANCE TO FIBRODYSPLASIA OSSIFICANS PROGRESSIVA?

H I Roach^[1], R S Tare^[1], R O C Oreffo^[1], E M Shore^[2], F S Kaplan^[2]. ^[1]University Orthopaedics, University of Southampton, CF86, General Hospital, Southampton, UK; ^[2]Dept. of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, USA

09:42

OC17 VITAMIN D RECEPTOR GENE POLYMORPHISMS: ASSOCIATION WITH BONE DENSITY AND OSTEOPOROTIC FRACTURES: A CASE CONTROL STUDY

A,Rogers, F Gossiel, J A Clowes, R Eastell. Bone Metabolism Group, Section of Human Metabolism, Division of Clinical Sciences (North), University of Sheffield, UK

09:54

OC18 C-FOS BLOCKS CARTILAGE DIFFERENTIATION IN VITRO BY INHIBITING THE EFFECTS OF BONE MORPHOGENETIC PROTEIN (BMP)-2 AND -4

I Anagnostopoulos, D P Thomas, A E Grigoriadis. Department of Craniofacial Development, King's College London, Guy's Hospital, Guy's Tower, London, UK

10:06

OC19 POLYMORPHISMS IN THE P450 C17 (17-HYDROXYLASE/17,20-LYASE) AND P450 C19 (AROMATASE) GENES : ASSOSIATION WITH SERUM SEX STEROIDS CONCENTRATIONS AND BONE MINERAL DENSITY IN POST-MENOPAUSAL WOMEN

J Somner^[1],S Mclellan^[1],J Cheung^[1],Y T Mak^[1], M L Frost^[2], K M Knapp^[2], A S Wiercbicki^[1], M Wheeler^[1], I Fogelman^[2], S H Ralston^[3], G Hampson^[1]. ^[1]Department of Chemical Pathology, St Thomas' Hospital, London, UK; ^[2]Osteoporosis Screening Unit, Guy's Hospital, London UK; ^[3]Bone Research Group, Department of Medicine and Therapeutics, University of Aberdeen Medical School, UK

10:18

OC20 EPIDEMIOLOGY OF FRACTURES IN BRITISH RACEHORSES IN TRAINING

K L P Verheyen^[1], J S Price^[2], J L N Wood^[1]. ^[1]Animal Health Trust, Newmarket, UK; ^[2]Royal Veterinary College, London, UK

10:30

Coffee

11:00

Poster Discussion Session

Chairs: Sharyn Bord (Cambridge, UK)/Juliet Compston (Cambridge, UK)

11:00

P1 GENDER VARIATION IN PTH SENSITIVITY FOLLOWING GROWTH HORMONE REPLACEMENT IN ADULT GROWTH HORMONE DEFICIENT PATIENTS

H D White^[1], A M Ahmad^[1], A A Syed^[1], R Peter^[1], B H Durham^[2], J P Vora^[1], W D Fraser^[2]. ^[1]Department of Diabetes and Endocrinology; ^[2]Department of Clinical Chemistry, Duncan Building, Royal Liverpool University Hospital, UK

11:05

P2 OSTEOPONTIN EXPRESSION AT SITES OF OSTEOCLAST EROSION IN RHEUMATOID ARTHRITIS

D O'Gradaigh, S Bord, J E Compston. Bone Research Group, Dept. of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK

11:10

P3 CHANGES IN BODY COMPOSITION DURING TREATMENT FOR CHILDHOOD ACUTE LYMPHOBLASTIC LEUKAEMIA WITH A CONTEMPORARY PROTOCOL

J H Davies^[1], B Evans^[1], M Jenney^[2], W Evans^[3], E Jones^[3],J Gregory^[3]. ^[1]Department of Child Health, UWCM, Cardiff, UK;^[2]Department of Paediatric Oncology, Llandough Hospital, UK; ^[3]Department of Medical Physics, UHW, Cardiff, UK

11:15

P4 ESTROGEN AND THE FORMATION OF REMODELLING CLUSTERS

N Loveridge, S Vedi, K L Bell, J E Compston, J Reeve. Department of Medicine, University of Cambridge Clinical School, UK

11:20

P5 IN VIVO HUMAN BONE AND CARTILAGE FORMATION USING POROUS POLYMER SCAFFOLDS ENCAPSULATED WITH BONE MORPHOGENETIC PROTEIN-2

X B Yang^[1], M J Whitaker^[2], N M P Clarke^[1], W Sebald^[3], S M Howdle^[2], K M Shakesheff^[4], R O C Oreffo^[1]. ^[1]University Orthopaedics, University of Southampton, Southampton General Hospital, UK; ^[2]School of Chemistry, University of Nottingham, UK; ^[3]Department of Physiological Chemistry, University of Wurzburg, Germany; ^[4]School of Pharmaceutical Sciences, University of Nottingham, UK

11:25

P6 PASTEURELLA MULTOCIDA TOXIN HAS DIFFERENTIAL EFFECTS ON MURINE AND HUMAN OSTEOCLAST DIFFERENTIATION AND ACTIVITY

N W A McGowan^[1], D Harmey^[1], G Stenbeck^[2], A E Grigoriadis^[1]. ^[1]Craniofacial Development, King's College London, UK; ^[2]Bone and Mineral Centre, University College London, UK

11:30

P7 TGF-BETA-INDUCED SOCS3 EXPRESSION AUGMENTS TNF-ALPHA-INDUCED OSTEOCLAST FORMATION

S W Fox^[1], A C Lovibond^[1], S J Haque^[2], T J Chambers^[1]. ^[1]Department of Cellular Pathology, St George's Hospital Medical School, London, UK; ^[2]Department of Cancer Biology & Department of Pulmonary Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, USA

11:35

P8 A ROLE FOR RETINOIC ACID IN REGULATING OSTEOCLAST FUNCTION IN REGENERATING DEER ANTLERS

S P Allen^[1], M Maden^[2], J S Price^[1]. ^[1]Veterinary Basic Sciences, Royal Veterinary College, London, UK; ^[2]Developmental Neurobiology, Kings College, London, UK

11:40

P9 OLDER PEOPLE IN CHINA AND UK DIFFER IN THE RELATIONSHIPS BETWEEN PARATHYROID HORMONE, VITAMIN D AND BONE MINERAL STATUS

L Yan^[1,2], A Prentice^[1], S D'Ath^[1], A Laidlaw^[1], M A Laskey^[1], B Zhou^[2]. ^[1]MRC Human Nutrition Research, Cambridge, UK; ^[2]Shenyang Medical College, Shenyang, PR China

11:45

P10 CORTICAL POROSITY DURING FAST GROWTH IN THE IMMATURE SKELETON: THE ROLE OF PERIOSTEAL OSTEOBLAST PROLIFERATION

D H Murray^[1], N Loveridge^[2], C Farquharson^[1]. ^[1]Bone Biology Group, Roslin Institute, Edinburgh, UK; ^[2]Bone Research Group, Addenbrooke's Hospital, Hills Road, Cambridge, UK

11:50

P11 ADHESION OF BREAST AND PROSTATE CANCER CELLS TO EXTRACELLULAR MATRIX PROTEINS IS DEPENDENT ON GROWTH FACTOR RECEPTOR EXPRESSION AND INHIBITED BY ZOLEDRONIC ACID

L M Pickering, J P Coxon, K W Colston. Department of Cellular and Molecular Medicine, St. George's Hospital Medical School, London, UK

11:55

P12 A NOVEL APPROACH TO THE GENERATION OF ANTIBODIES AGAINST ADULT HUMAN MESENCHYMAL STEM CELLS

J Letchford^[1], A Cardwell^[1], K Stewart^[1], M J Perry^[2], J N Beresford^[1]. ^[1]University of Bath, UK; ^[2]University of Bristol, UK

12:00

Bone and Tooth Society AGM, Lunch

13:00

Oral Communications

Chairs: Richard Oreffo (Southampton, UK)/Larry Suva (Little Rock AR, USA)

13:00

OC21 ER ALPHA ACTIVATES THE BMP-6 PROMOTER IN BONE AND BREAST CELLS VIA DISTINCT MECHANISMS

D B Ong^[1], S M Colley^[1], M R Norman^[1], R Kitazawa^[2], S Kitazawa^[2], J H Tobias^[1]. ^[1]Academic Rheumatology and University Research Centre for Neuroendocrinology, University of Bristol, UK; ^[2]2nd Department of Pathology, Kobe University, Kobe, Japan

13:12

OC22 NEURONAL NOS IN ADULT HUMAN CORTICAL OSTEOCYTES

A M Caballero-Alías^[1], N Loveridge^[1], A Lyon^[1], V Das-Gupta^[2], A Pitsillides^[2], J Reeve^[1]. ^[1]Bone Research Group (MRC), University of Cambridge, UK; ^[2]Royal Veterinary College, London, UK

13:24

OC23 BIOMIMETIC MICROENVIRONMENTS - STIMULATION OF HUMAN OSTEOPROGENITOR DIFFERENTIATION BY A SYNTHETIC PEPTIDE COLLAGEN BINDING DOMAIN: P-15

X B Yang^[1], H I Roach^[1], N M P Clarke^[1], R S Bhatnagar^[2], S Li^[3], R O C. Oreffo^[1]. ^[1]University Orthopaedics, University of Southampton, General Hospital, Southampton, UK; ^[2]Laboratory of Connective Tissue Biochemistry, University of California San Francisco, USA; ^[3]Department of Bioengineering, University of California Berkeley, USA

13:36

OC24 DEFINING THE SECRETOME OF BONE CELLS: NOVEL BONE BIOACTIVE PROTEINS

G P Thomas, P Moffatt, P Salois, M-C Bessette, K Sellin, M-H Gaumond, C Lanctot. Phenogene Therapeutiques, 416 de Maisonneuve Ouest, Suite 1020, Montreal, Quebec H3A 1L2, Canada.

13:48

OC25 ACTIVATORS OF PPAR ISOFORMS ALPHA AND/OR DELTA CAUSE AN INCREASE IN BONE FORMATION IN VITRO AND IN VIVO

J Clarke^[1], D Hughes^[2], M Perry^[3], A Scutt^[1], K Still^[1]. ^[1]Child Health, University of Sheffield, UK

14:00

Symposium: Insights from rare diseases

Chair: Roger Smith (Oxford, UK)

14:00

IS12 Molecular pathology of renal chloride channels and calcium metabolism: Raj Thakker (Oxford, UK)

14:30

IS13 Juvenile Pagets, OPG mutations: Tim Cundy (Auckland, New Zealand)

15:00

Presentation of Awards

15:15

Close of meeting