P1

GENDER VARIATION IN PTH SENSITIVITY FOLLOWING GROWTH HORMONE REPLACEMENT IN ADULT GROWTH HORMONE DEFICIENT PATIENTS

H D White^[1], A M Ahmad^[1], A A Syed^[1], R Peter^[1], B H Durham^[2], J P Vora^[1], W D Fraser^[2]. ^[1]Department of Diabetes and Endocrinology; ^[2]Department of Clinical Chemistry, Duncan Building, Royal Liverpool University Hospital, UK

P2

OSTEOPONTIN EXPRESSION AT SITES OF OSTEOCLAST EROSION IN RHEUMATOID ARTHRITIS

D O'Gradaigh, S Bord, J E Compston. Bone Research Group, Dept. of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK

P3

CHANGES IN BODY COMPOSITION DURING TREATMENT FOR CHILDHOOD ACUTE LYMPHOBLASTIC LEUKAEMIA WITH A CONTEMPORARY PROTOCOL

J H Davies^[1], B Evans^[1], M Jenney^[2], W Evans^[3], E Jones^[3],J Gregory^[3]. ^[1]Department of Child Health, UWCM, Cardiff, UK;^[2]Department of Paediatric Oncology, Llandough Hospital, UK; ^[3]Department of Medical Physics, UHW, Cardiff, UK

P4

ESTROGEN AND THE FORMATION OF REMODELLING CLUSTERS

N Loveridge, S Vedi, K L Bell, J E Compston, J Reeve. Department of Medicine, University of Cambridge Clinical School, UK

P5

IN VIVO HUMAN BONE AND CARTILAGE FORMATION USING POROUS POLYMER SCAFFOLDS ENCAPSULATED WITH BONE MORPHOGENETIC PROTEIN-2

X B Yang^[1], M J Whitaker^[2], N M P Clarke^[1], W Sebald^[3], S M Howdle^[2], K M Shakesheff^[4], R O C Oreffo^[1]. ^[1]University Orthopaedics, University of Southampton, Southampton General Hospital, UK; ^[2]School of Chemistry, University of Nottingham, UK; ^[3]Department of Physiological Chemistry, University of Wurzburg, Germany; ^[4]School of Pharmaceutical Sciences, University of Nottingham, UK

P6

PASTEURELLA MULTOCIDA TOXIN HAS DIFFERENTIAL EFFECTS ON MURINE AND HUMAN OSTEOCLAST DIFFERENTIATION AND ACTIVITY

N W A McGowan^[1], D Harmey^[1], G Stenbeck^[2], A E Grigoriadis^[1]. ^[1]Craniofacial Development, King's College London, UK; ^[2]Bone and Mineral Centre, University College London, UK

P7

TGF-BETA-INDUCED SOCS3 EXPRESSION AUGMENTS TNF-ALPHA-INDUCED OSTEOCLAST FORMATION

S W Fox^[1], A C Lovibond^[1], S J Haque^[2], T J Chambers^[1]. ^[1]Department of Cellular Pathology, St George's Hospital Medical School, London, UK; ^[2]Department of Cancer Biology & Department of Pulmonary Critical Care Medicine, Cleveland Clinic Foundation, Cleveland, USA

P8

A ROLE FOR RETINOIC ACID IN REGULATING OSTEOCLAST FUNCTION IN REGENERATING DEER ANTLERS

S P Allen^[1], M Maden^[2], J S Price^[1]. ^[1]Veterinary Basic Sciences, Royal Veterinary College, London, UK; ^[2]Developmental Neurobiology, Kings College, London, UK

P9

OLDER PEOPLE IN CHINA AND UK DIFFER IN THE RELATIONSHIPS BETWEEN PARATHYROID HORMONE, VITAMIN D AND BONE MINERAL STATUS

L Yan^[1,2], A Prentice^[1], S D'Ath^[1], A Laidlaw^[1], M A Laskey^[1], B Zhou^[2]. ^[1]MRC Human Nutrition Research, Cambridge, UK; ^[2]Shenyang Medical College, Shenyang, PR China

P10

CORTICAL POROSITY DURING FAST GROWTH IN THE IMMATURE SKELETON: THE ROLE OF PERIOSTEAL OSTEOBLAST PROLIFERATION

D H Murray^[1], N Loveridge^[2], C Farquharson^[1]. ^[1]Bone Biology Group, Roslin Institute, Edinburgh, UK; ^[2]Bone Research Group, Addenbrooke's Hospital, Hills Road, Cambridge, UK

P11

ADHESION OF BREAST AND PROSTATE CANCER CELLS TO EXTRACELLULAR MATRIX PROTEINS IS DEPENDENT ON GROWTH FACTOR RECEPTOR EXPRESSION AND INHIBITED BY ZOLEDRONIC ACID

L M Pickering, J P Coxon, K W Colston. Department of Cellular and Molecular Medicine, St. George's Hospital Medical School, London, UK

P12

A NOVEL APPROACH TO THE GENERATION OF ANTIBODIES AGAINST ADULT HUMAN MESENCHYMAL STEM CELLS

J Letchford^[1], A Cardwell^[1], K Stewart^[1], M J Perry^[2], J N Beresford^[1]. ^[1]University of Bath, UK; ^[2]University of Bristol, UK

P13

THE ISSUE OF BIORESORPTION OF THE BIO-OSS XENOGENEIC BONE SUBSTITUTE IN BONE DEFECTS

M Duda^[1], J Pajak^[2]. ^[1]Silesia - Med Oral Medicine Clinic, Katowice, Poland; ^[2]Chair and Institute of Pathomorphology of the Silesian University of Medicine, Katowice, Poland

P14

MORPHOLOGY OF ROOT CANALS CROSS-SECTIONS OF RESECTED ROOTS OF FIRST AND SECOND LOWER MOLARS

M Duda, A Skoczek, B Kowal, A Komorek. Silesia - Med Oral Medicine Clinic, Katowice, Poland

P15

MINERAL BIOMIMICRY- GENERATION OF BIOMIMETIC MICROPOROUS CALCIUM CARBONATE SPHERES FOR SKELETAL REGENERATION

D W Green^[1], D Walsh^[2], K A,Partridge^[1], S,Mann^[2], R O C Oreffo^[2]. ^[1]University Orthopaedics, General Hospital, Tremona Road, Southampton, UK; ^[2]Department of Chemistry, University of Bristol, UK

P16

INTERLEUKIN-10 DIRECTLY INHIBITS RANKL-INDUCED OSTEOCLAST FORMATION FROM MONONUCLEAR PHAGOCYTE PRECURSORS

A C Lovibond, T J Chambers, S W Fox. Department of Cellular Pathology, St George's Hospital Medical School, London, UK

P17

DURATION AND DEPTH OF RESORPTION DURING CANCELLOUS BONE REMODELING CAN BE SIMULATED BY CHANGES IN CELLULAR ACTIVITY USING MICHAELIS-MENTEN EQUATIONS AND THE INTERACTIVE EFFECTS OF RANKL, RANK, OPG AND TGF-BETA1 ON OSTEOCLAST SURVIVAL AND FUNCTION

M J Martin, J C Buckland-Wright. Applied Clinical Anatomy Research, King's College London, Guys Campus, London Bridge, London, UK

P18

RATES OF BONE FORMATION AND MINERALIZATION DURING CANCELLOUS BONE REMODELING CAN BE SIMULATED BY CELL PROLIFERATION AND MICHAELIS-MENTEN EQUATIONS THAT DESCRIBE OSTEOBLAST ACTIVITY

M J Martin, J C Buckland-Wright. Applied Clinical Anatomy Research, King's College London, Guys Campus, London Bridge, London, UK

P19

CHONDROCYTES FROM THE OSTEOPETROTIC MUTATION TOOTHLESS (TL)/ CSF-1 NULL RAT DIFFERENTIATE IN VITRO

A Gartland, A Mason-Savas, C A MacKay, S C Marks Jr., P R Odgren. University of Massachusetts Medical School, Worcester, MA, USA.

P20

THE PROMISING IMPLANTABLE MATERIAL THE FLUORINATED 'LITAR'

S D Litvinov^[1], T M Kosyreva^[2], A S Seryogin^[2], T V Sudakova^[1]. ^[1]Samara State Technical University, Samara, Russia; ^[2]The Regional Clinical M.I. Kalinin Hospital, Samara, Russia

P21

EFFECT OF HYDROCORTISONE ON CORTICOSTEROID RECEPTOR MRNA LEVELS IN CULTURED HUMAN OSTEOBLASTS DEPENDS ON THE STATE OF DIFFERENTIATION OF THE CELLS

D C Ireland, S Bord, S R Beavan, J E Compston. University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK

P22

ASSOCIATIONS IN BONE TURNOVER BETWEEN THE ENDOCORTICAL AND CORTICAL COMPARTMENTS OF THE HUMAN FEMORAL NECK

J Power^[1], N Loveridge^[1], A Lyon^[1], N Rushton^[2], M Parker^[3], J Reeve^[1]. ^[1]Bone Research Group (MRC); ^[2]Orthopaedic Research Unit, University of Cambridge, UK; ^[3]Peterborough District Hospital, UK

P23

REGULATION OF OSTEOBLASTS BY ACTIVATORS OF THE LXR AND FXR NUCLEAR RECEPTORS

J Clarke, K Still. University of Sheffield, UK.

P24

THE DIFFERENTIAL EFFECTS OF PHOSPHATIDYLINOSITOL 3-KINASE ON OSTEOBLASTIC DIFFERENTIATION BY PROSTAGLANDIN E2

J Ragoobir, A A Pitsillides, and N T Goode.<BR>Department of Veterinary Basic Sciences, Royal Veterinary College, London NW1 0TU, UK.

P25

PROTEIN KINASE C MODULATES THE ROLE OF EXTRACELLULAR SIGNAL-REGULATED PROTEIN KINASES IN PROSTAGLANDIN E2-INDUCED OSTEOBLAST DIFFERENTIATION

J Ragoobir, K Doorty, M Avella, A A Pitsillides, and N T Goode. Department of Veterinary Basic Sciences, Royal Veterinary College, London NW1 0TU, UK

P26

SOYBEAN ISOFLAVONES AND RALOXIFEN IN POSTMENOPAUSALWOMEN WITH BONE MASS LOSS

A Bazarra-Fernández^[1], M A Bazarra-Castro^[2]. ^[1]Health Science Dept, University of La Coruña; ^[2]University of Santiago de Compostela, Spain.

P27

AUTOTRANSPLANTED TOOTH FROM TISSUE BANK AS ABUTMENT FOR PERMANENT PARTIAL DENTURE - DESCRIPTION OF A CASE

M Duda^[1], H Bursig^[2]. ^[1]Silesia - Med Oral Medicine Clinic, Katowice, Poland; ^[2]Tissue Bank of the Provincial Blood-Service Centre, Katowice, Poland

P28

BONE TURNOVER IN MALES WITH BETA-THALASSAEMIA MAJOR

N Bhargava^[1], T Dew^[1], A Stephens^[2], C Moniz^[1]. Department of ^[1]Clinical Biochemistry and ^[2]Haematology, Kings College Hospital, London, UK

P29

COMPARISON OF PTH SECRETION AND BONE METABOLISM IN ADULT GROWTH HORMONE DEFICIENT PATIENTS WITH NORMAL AND REDUCED BONE MINERAL DENSITY

H D White^[1], A M Ahmad^[1], S Chandran^[1], K Prabhakar^[1], B H Durham^[2], J P Vora^[1], W D Fraser^[2]. ^[1]Department of Diabetes and Endocrinology; ^[2]Department of Clinical Chemistry, Duncan Building, Royal Liverpool University Hospital, UK

P30

MARKERS OF BONE TURNOVER AND DISEASE STATUS IN PROSTATE CANCER

R A Hannon^[1], J M Wells^[2], F C Hamdy^[2], N Hoyle^[3], R Eastell^[1]. ^[1]Bone Metabolism Group, Division of Clinical Sciences(North); ^[2]Academic Urology Unit, University of Sheffield, UK; ^[3]Roche Diagnostics GmbH, Penzberg, Germany

P31

BONE MASS ACQUISITION DURING CHILDHOOD IS RELATED TO TOTAL ENERGY INTAKE IN INFANCY

J H Tobias^[1], C Steer^[2], P M Emmett^[2], A R Ness^[2], J Golding^[2], C Cooper^[3], and the ALSPAC Bone Group. ^[1]Rheumatology Unit; ^[2]ALSPAC, University of Bristol, UK; ^[3]MRC Environmental Epidemiology Unit, Southampton, UK

P32

BONE DENSITY, BODY COMPOSITION AND BONE TURNOVER IN HEALTHY AND OSTEOPOROTIC MEN

S F Evans, C A Sharp, H Davies, I W Chantler, M W J Davie. Charles Salt Centre, Robert Jones & Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire, UK

P33

BONE TURNOVER FOLLOWING TIBIAL SHAFT FRACTURE

S W Veitch^[1,2], S C Findlay^[1], A J Hamer^[2], A Blumsohn^[1], R Eastell^[1], B M Ingle^[1]. ^[1]Bone Metabolism Group, Clinical Sciences (North), University of Sheffield, UK; ^[2]Orthopaedic Department, Northern General Hospital, Sheffield, UK

P34

ACCURACY AND PRECISION OF PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY MEASUREMENTS AT THE TIBIAL METAPHYSIS

S W Veitch^[1,2], S C Findlay^[1], B M Ingle^[1], C J Ibbotson^[3], A J Hamer^[2], R Eastell^[1]. ^[1]Bone Metabolism Group, Clinical Sciences (North), University of Sheffield, UK; ^[2]Orthopaedic Department; ^[3]Tissue Bank, Northern General Hospital, Sheffield, UK

P35

VISUAL IDENTIFICATION OF PREVALENT VERTEBRAL FRACTURES: COMPARISON BETWEEN METHODS

G Jiang^[1], L Ferrar^[1], N A Barrington^[2], R.Eastell^[1]. ^[1]Bone Metabolism Group, Division of Clinical Sciences, University of Sheffield, UK; ^[2]Diagnostic Imaging, Northern General Hospital Trust, Sheffield, UK

P36

VITAMIN D STATUS OF DEPRIVED CHILDREN IN DELHI, INDIA: SEASONAL VARIATION & THE EFFECT OF ORAL VITAMIN D SUPPLEMENTATION

M Z Mughal^[1], R Mittal^[2], V Taneja^[2], R Khanna^[3], A Kumar^[3], V Sreenivas^[3], P Upadhyay^[4], J L Berry^[5], J M Puliyel^[2]. ^[1]Department of Paediatric Medicine, St Mary's Hospital, Manchester, UK; ^[2]St Stephens Hospital, Delhi, India; ^[3]Department of Community Medicine, St Stephens Hospita, Delhi, India; ^[4]Center for Science Education and Communication, University of Delhi, India; ^[5]Department of Medicine, University of Manchester, UK

P37

THE EFFECT OF CALCIUM SUPPLEMENTATION ON LEPTIN LEVELS, FAT ACCUMULATION AND MENARCHE

K Ghatge^[1], A Rogers^[2], M E Barker^[1], R Eastell^[2]. ^[1]Centre for Human Nutrition; ^[2]Bone Metabolism Group, University of Sheffield, UK

P38

SEMI-AUTOMATED METACARPAL MORPHOMETRY (METACARPAL CORTICAL INDEX) PREDICTS FRACTURE RISK IN ELDERLY WOMEN

S Vasireddy, S K Bal, L Reaney, J A Kanis, E V McCloskey. WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, UK

P39

VITAMIN D STATUS ACROSS EUROPE : IMPACT OF GEOGRAPHICAL LOCATION, SEASON, AND BODY WEIGHT

A Blumsohn^[1], C C Glüer^[2], D M Reid^[3], D Felsenberg^[4], C Roux^[5], R Eastell^[1]. ^[1]University of Sheffield, UK; ^[2]University Hospital Kiel, Germany; ^[3]University of Aberdeen, UK; ^[4]Free University Berlin, Germany; ^[5] Rene Descartes University, Paris, France

P40

DIGITAL X-RAY RADIOGRAMMETRY OF THE METACARPALS IN PAEDIATRIC SUBJECTS

R L Ashby^[1], K A Ward^[1], M Z Mughal^[2], J E Adams^[1]. ^[1]The University of Manchester, UK; ^[2]Saint Mary's Hospital, Manchester, UK

P41

SERUM INTACT AND C-TERMINAL FGF-23 FOLLOWING ACUTE AND CHRONIC PHOSPHATE SUPPLEMENTATION

H C Allen^[1], S Fukumoto^[2], T Yamashita^[3], A Whybro^[1], R Eastell^[1], A Blumsohn^[1]. ^[1]Bone Metabolism Group, Division of Clinical Sciences, University of Sheffield, UK; ^[2]Laboratory Medicine, University of Tokyo, Japan; ^[3]Pharmaceutical Research Laboratories, Kirin Brewery Co., Takasaki, Japan

P42

RELATIONSHIP BETWEEN BONE MARKERS, AGE AT START OF TRAINING, AND RISK OF FRACTURE AND FATIGUE INJURY OF THE THIRD METACARPAL BONE IN TWO YEAR OLD RACEHORSES

B F Jackson^[1], C Lonnell^[1], K Verheyen^[2], D U Pfeiffer^[1], J S Price^[1]. ^[1]Department of Veterinary Basic Sciences and Department of Veterinary Clinical Sciences, The Royal Veterinary College, London, UK; ^[2]Epidemiology Unit, The Animal Health Trust, Newmarket, UK

P43

BONE MINERAL DENSITY (BMD) IN CHILDHOOD SURVIVORS OF ACUTE LYMPHOBLASTIC LEUKAEMIA (ALL) TREATED WITHOUT CRANIAL IRRADIATION (XRT)

M Z Mughal^[1], C Beane^[2], E Auld^[2], S M Shalet^[2], O B Eden^[2], R F Stevens^[2], A Will^[2], S A Roberts^[3], J E Adams^[3], B M D Brennan^[1]. ^[1]Central Manchester & Manchester Children's University Hospitals, UK; ^[2]Christie Hospital, Manchester, UK; ^[3]University of Manchester, UK.

P44

SOURCE OF MATERNAL SERUM OSTEOPROTEGERIN DURING HUMAN PREGNANCY

K E Naylor^[1], A Rogers^[1], C Smith^[1], V Hall^[2], R B Fraser^[2], I Holen^[3], J Lippitt^[3], REastell^[1], A Blumsohn^[1]. ^[1]Bone Metabolism Group; ^[2]Obstetrics and Gynaecology; ^[3]Clinical Oncology, University of Sheffield, UK

P45

ROLE OF OSTEOPROTEGERIN GENE POLYMORPHISMS IN OSTEOARTHRITIS

S L Curtis, L Keen, J Bidwell, M J Perry. University of Bristol, UK

P46

THE RELIABILITY OF FOLTIN'S CLASSIFICATION FOR ASSESSING THE BONE QUALITY OF THE PROXIMAL TIBIA.

A Bonshahi, A M Ali, D Smith, L Yang, M Saleh Division of Clinical Sciences, Northern General Hospital,Sheffield

P47

HOMOCYSTINURIA PRESENTING WITH PREGNANCY ASSOCIATED OSTEOPOROSIS

A Y N Lim^[1], J Calvin^[2], A J Crisp^[1]. Departments of ^[1]Metabolic Bone Diseases; ^[2]Clinical Biochemistry, Addenbrooke's Hospital, Cambridge, UK

P48

SEVERE BONE DISEASE IN PRIMARY HYPERPARATHYROIDISM IN A BRITISH ASIAN ADOLESCENT

M S Cooper^[1], J B Campbell^[2], M D Shrivastava^[2], N J Gittoes^[1]. ^[1]University of Birmingham, UK; ^[2]Heartlands Hospital, Birmingham, UK