Thursday 10 July

08:45

IS6 Paracrine regulation of postmenopausal increases in bone resorption: role of RANK Ligand (RANKL): Larry Riggs (Rochester MN, USA)

Chair: Richard Eastell (Sheffield, UK)

09:30

Oral Communications

Chairs: Agi Grigoriadis (London, UK)/Nigel Loveridge (Cambridge, UK)

09:30

OC6 MEGAKARYOCYTE SYNTHESIS OF OSTEOPROTEGERIN IS STIMULATED BY ESTROGEN WHILST RANKL EXPRESSION IS SUPPRESSED

S Bord^[1], E Frith^[1,2], D C Ireland^[1], M A Scott^[2], J I O Craig^[2], J E Compston^[1]. ^[1]Cambridge University School of Clinical Medicine; ^[2]Department of Haematology, Addenbrooke's Hospital, Cambridge, UK

09:42

OC7 MEGAKARYOCYTES STIMULATE OSTEOBLAST SYNTHESIS OF COLLAGEN AND OSTEOPROTEGERIN PROTEIN AND mRNA

S Bord^[1], E Frith^[1,2], D C Ireland^[1], M A Scott^[2], J I O Craig^[2], J E Compston^[1]. ^[1]Cambridge University School of Clinical Medicine; ^[2]Department of Haematology, Addenbrooke's Hospital, Cambridge, UK

09:54

OC8 REGULATION OF BONE RESORPTION AND FORMATION THROUGH THE CELL-SURFACE PROCESSING OF RANKL AND  JAGGED-1

D J Dallas-Skerry^[1], G Murphy^[2], T M Skerry^[1]. ^[1]Royal Veterinary College, London, UK; ^[2]Cambridge Institute for Medical Research, UK

10:06

OC9 INNOVATIVE BIOMINERALISED POLYSACCHARIDE TEMPLATES FOR HUMAN BONE CELL AND GENE DELIVERY

D W Green^[1], I Leveque^[2], D Walsh^[2], K A Partridge^[1], S Mann^[2], R O C Oreffo^[2]. ^[1]University Orthopaedics, General Hospital, Tremona Road, Southampton, UK; ^[2]Department of Chemistry, University of Bristol, UK

10:18

OC10 RETARDATION OF LONGITUDINAL BONE GROWTH BY GLUCOCORTICOIDS IS REVERSED BY IGF-I IN FOETAL MOUSE   METATARSAL ORGAN CULTURES

T Mushtaq, S F Ahmed, C Farquharson. Bone Biology Group, Division of Integrative Biology, Roslin Institute, Roslin, UK

10:30

IS7 Bone microstructure in archaeology: Andrew Chamberlain (Sheffield, UK)

Chair: Aubrey Blumsohn (Sheffield, UK)

10:50

Coffee

11:20

Symposium: New hormonal actions

Chairs: Jonathan Reeve (Cambridge, UK)/David Reid (Aberdeen, UK)

11:20

IS8 Phosphate metabolism: Gordon Strewler (Boston MA, USA)

11:50

IS9 Osteoblast sensitivity to corticosteroiods: Mark Cooper (Birmingham, UK)

12:20

IS10 Thyroid hormone actions in bone and cartilage: Graham Williams (London, UK)

12:50

Lunch

14:00

Clinical Case Presentations

Moderators: Tim Cundy (Auckland, NZ)/Michael Whyte (St Louis MO, USA)

14:00

C1 RIB FRACTURES IN A YOUNG MAN

M W J Davie. Robert Jones and Agnes Hunt Hospital, Oswestry, Shropshire, UK

14:15

C2 CHONDROSARCOMA ASSOCIATED WITH HYPERPARATHYROIDISM: A REPORT OF 2 CASES

A Bhatia^[1], S Cannon^[1], T Briggs^[1], R W Keen^[1,2]. ^[1]Royal National Orthopaedic Hospital, Metabolic Bone Unit, Brockley Hill, Stanmore, Middlesex, UK; ^[2]University College London, Rheumatology Department, Arthur Stanley House, 40-50 Tottenham Street, London, UK

14:30

C3 MOLECULAR DIAGNOSIS OF HYPOPARATHYROIDISM : 2 ILLUSTRATIVE CASES

G Hampson^[1], M R Bowl^[2], M A Nesbit^[2], M Giannoulis^[3], R Jones^[3], R V Thakker^[2]. ^[1]Department of Chemical Pathology, St Thomas' Hospital, London, UK; ^[2]Nuffield Department of Clinical Medicine, University of Oxford, UK; ^[3]Diabetes and Endocrine, St Thomas' Hospital, London, UK

14:45

C4 SEVERE OSTEOPOROSIS IN TWO YOUNG IMMOBILISED MEN

D O'Gradaigh, S Bord, J E Compston. Bone Research Group, Dept. of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK

15:00

Oral Communications

Chairs: Larry Riggs (Rochester MN, USA)/Peter Selby (Manchester, UK)

15:00

OC11 THE EFFECTS OF DIETARY IMPROVEMENT ON BONE  METABOLISM IN ELDERLY UNDERWEIGHT WOMEN WITH OSTEOPOROSIS : A RANDOMISED CONTROLLED TRIAL

G Hampson^[1], F Martin^[2], K Moffat^[3], S Vaja^[1], S Sankaralingam^[1], J Cheung^[1], G M Blake^[4], I Fogelman^[4]. ^[1]Department of Chemical Pathology; ^[2]Elderly Care Unit; ^[3]Dietetics, St Thomas' Hospital, London, UK; ^[4]Osteoporosis Screening Unit, Guy's Hospital, London, UK

15:12

OC12 CHANGES IN BONE MASS FOLLOWING TIBIAL SHAFT FRACTURE

S W Veitch^[1,2], S C Findlay^[1], A J Hamer^[2], R Eastell^[1], B M Ingle^[1]. ^[1]Bone Metabolism Group, Clinical Sciences (North), University of Sheffield, UK; ^[2]Orthopaedic Department, Northern General Hospital, Sheffield, UK

15:24

OC13 DOES LOW MAGNITUDE, HIGH FREQUENCY MECHANICAL LOADING IMPROVE DIAPHYSEAL STRENGTH OF LONG BONES?

K A Ward^[1], C W Alsop^[1], J M Caulton^[2], C T Rubin^[3], M Lunt^[1], J E Adams^[1], M Z Mughal^[2]. ^[1]University of Manchester, UK; ^[2]Central Manchester and Manchester Children's University Hospitals NHS Trust, UK; ^[3]State University of New York, New York, USA.

15:36

OC14 BIOCHEMICAL MARKERS OF BONE TURNOVER ARE ASSOCIATED WITH RISK OF BONE METASTASES IN WOMEN WITH PRIMARY OPERABLE BREAST CANCER

S K Bal^[1], R Tahtela^[2], A Paterson^[3], T Powles^[4], S Atula^[2], J Kanis^[1], S Vasireddy^[1], J Nevalainen^[2], E McCloskey^[1]. ^[1]University of Sheffield, UK; ^[2]Leiras Oy, Clinical Research, Helsinki, Finland; ^[3]Tom Baker Cancer Center, Calgary, Canada; ^[4]Royal Marsden Hospital, Sutton, UK

15:48

OC15 THE RELATIONSHIP BETWEEN BONE DENSITY BONE SIZE AND FRACTURE SYNDROMES IN POSTMENOPAUSAL WOMEN

C M Smith, J A Clowes, R Eastell. Bone Metabolism Group, University of Sheffield, UK

16:00

Tea and Posters

17:00

Debate:

Clinical trials without placebo controls are unethical.

For: John Kanis (Sheffield, UK)

Against: Juliet Compston (Cambridge, UK)

Chair: David Hosking (Nottingham, UK)

19:30

Dinner