WEDNESDAY 4 JULY

07:55

Crombie and Kings Hall residents – bus to AECC

Signalling pathways and bone formation

Chairs: Brendon Noble (Edinburgh, UK) and Jon Tobias (Bristol, UK)

08:30

IS7

Control of bone remodeling homeostasis via the autonomous nervous system
Florent Elefteriou (Nashville, USA) 

09:00

IS8

Discovery of the fibrodysplasia ossificans dysplasia (FOP) gene
Matthew Brown (Brisbane, Australia)

09:30

IS9

Role of sclerostin in BMP and Wnt signalling: implications for bone formation
Wendy Balemans (Antwerp, Belgium)

10:00

Oral communications 3

Chairs: Matthew Brown (Brisbane, Australia) and Claire Clarkin (London, UK)

10:00

OC11

An atypical mutation in the activin A receptor, type 1 gene (ACVR1) in a severely affected fibrodysplasia ossificans progressiva patient
KA Petrie*, JJ Pointon, R Smith, RGG Russell, PW Wordsworth, JT Triffitt
Institute of Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford OX120JH, UK

10:12

OC12

Osteocyte sclerostin expression: regulator of BMU balance in osteoarthritis and osteoporosis?
N Loveridge^[1], J Power^[1], A Caballero-Alias^[1], R van Bezooijen^[2], S Papapoulos^[2], C Lowik^[2], KE Poole^[1], J Reeve^[1]*
^[1]University of Cambridge, Cambridge, UK;^[2]University of Leiden, Leiden, The Netherlands

10:24

OC13

Interrogating the mechanisms controlling osteocytogenesis
M Prideaux*^[1,2], A Pitsillides^[2], L Bonewald^[3], N Loveridge^[4], C Farquharson^[1]
[1]Roslin Institute, Edinburgh, UK;^[2]Royal Veterinary College, London, UK;^[3]School of Dentistry, University of Missouri-Kansas City, USA;^[4]University of Cambridge, Cambridge, UK

10:36

OC14

Spondyloepiphyseal dysplasia tarda (SEDT)-associated Sedlin mutations disrupt interactions with c-myc promoter-binding protein 1 (MBP-1), pituitary homeobox 1 (Pitx1) and steroidogenic factor 1 (SF1)
MA Nesbit*^[1], J Jeyabalan^[1], HA Ingraham^[2], RV Thakker^[1]
[1]Academic Endocrine Unit, Nuffield Department of Clinical Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK;^[2]Department of Physiology, University of California, San Francisco, California, USA

10:48

OC15

Wnt signalling upregulates osteoblast differentiation in zebrafish: a novel model for studies in osteoblastogenesis
PM Elks*, N Li, HH Roehl, PI Croucher
University of Sheffield, Sheffield, UK

11.00

Coffee

Bone loss and inflammatory arthritis

Chairs: Cyrus Cooper (Southampton, UK) and Richard Keen (London, UK)

11:30

IS10

Determinants of bone destruction in rheumatoid arthritis
Steven Goldring (New York, USA)

12:00

IS11

Role of cytokines and bone: use of in vitro models
Matt Gillespie (Melbourne, Australia)

12:30

IS12

Modulation of T cell function in rheumatoid arthritis
Berent Prakken (Utrecht, Netherlands)

13:00

Lunch and posters (even numbers attended 13:30-14:30)

14:30

Oral communications 4

Chairs: Kay Colston (London, UK) and Florent Elefteriou (Nashville, USA)

14:30

OC16

The local and sytemic effects of glucocorticoid generation in synovium
RS Hardy ^[1]*,EH Rabbitt ^[1], K Raza ^[2], CD Buckley ^[2], PM Stewart ^[1], MC Cooper ^[1]
[1]Division of Medical Sciences, University of Birmingham, West Midlands, UK;^[2]Division of Rheumatology, University of Birmingham, West Midlands, UK

14:42

OC17

Auto-induction of IL-1beta and loss of promoter methylation: a possible explanation of the unremitting progression of osteoarthritis?
MB Gibson^[1], K Hashimoto[1,2], HI Roach*^[1]
[1]Bone & Joint Research Group, University of Southampton, UK;^[2]Tohoku University, Sendai, Japan

14:54

OC18

Identification of lipocalin 2, a novel glucocorticoid responsive gene in growth plate chondrocytes
HC Owen*^[1][2], SF Ahmed^[2], C Farquharson^[1]
[1]Bone Biology Group, Roslin Institute, Edinburgh, UK;^[2]Bone & Endocrine Research Group, Royal Hospital for Sick Children, Glasgow, UK

15:06

OC19

Childhood physical activity is associated with bone mass at 4 years
N Harvey*^[1], K Westgate^[2], S Brage^[2], L Greenaway^[1], J Poole^[1], E Dennison^[1], H Inskip^[1], K Godfrey^[1], N Wareham^[2], U Ekelund^[2], C Cooper^[1]
[1]MRC Epidemiology Resource Centre, Southampton, UK;^[2] MRC Epidemiology Unit, Cambridge, UK

15:18

OC20

Body Mass Index is more predictive of the osteogenic potential of bone marrow stromal cells than age in males
RM McCann*^[1], GR Jordan^[1], D Beverland^[2], SA Clarke^[1]
[1]Trauma Research Group, Queen's University, Belfast, UK;^[2]Department of Orthopaedic Surgery, Musgrave Park Hospital, Belfast, UK

15:30

OC21

Genetic manipulation of human mesenchymal progenitors to promote chondrogenesis within polysaccharide templates
JC Babister*, RS Tare, DW Green, S Inglis, ROC Oreffo
Bone & Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, Southampton, SO16 6YD, UK

15:42

OC22

A soluble activin type II receptor prevents myeloma bone disease
AD Chantry*^[1], D Heath^[1], L Coulton^[1], O Gallagher^[1], H Evans^[1], J Seehra^[2], K Vanderkerken^[3], PI Croucher^[1]
[1]Section of Musculoskeletal Science, University of Sheffield Medical School, Sheffield, UK;^[2]Acceleron Pharma, Cambridge, MA, USA;^[3]Department Hematology and Immunology, Vrije Universiteit Brussel (VUB), Brussels, Belgium

16:00

Tea

16:30

Oral posters

Chairs: Richard Aspden (Aberdeen, UK) and Helen MacDonald (Aberdeen, UK)

16:30

OP1

Segmental bone regeneration using vascular endothelial growth factor encapsulated poly D,L-Lactic Acid scaffolds and human bone marrow stromal cells
JM Kanczler*^[1], J Barry^[2], P Ginty^[2], SM Howdle^[2], KM Shakesheff^[2], ROC Oreffo^[1]
[1] Bone & Joint Group, University of Southampton, UK;^[2]School of Pharmacy & Chemistry, University of Nottingham, UK

16:35

OP2

CP55940, a non-selective CB1/CB2 agonist, stimulates bone resorption by human osteoclasts in vitro
L Whyte*, S Ridge, R Ross, MJ Rogers
Aberdeen OBRP Centre, Bone & Musculoskeletal Research Programme, University of Aberdeen, UK

16:40

OP3

Dietary flavonoid intake is associated with bone mineral density in early postmenopausal Scottish women
AC Hardcastle*^[1,2], JAM Kyle^[2], G Duthie^[3], G Mc Neill^[2], DM Reid^[1,2], HM MacDonald^[1,2]
[1]Osteoporosis Research Unit, Health Sciences Building, University of Aberdeen, UK;^[2]College of Medicine, University of Aberdeen, UK;^[3]Rowett Research Institute, Aberdeen, UK

16:45

OP4

Femoral neck microarchitecture: differences between cases of hip fracture and controls
N Loveridge*^[1], J Power^[1], H Kroger^[2], M Parker^[3], J Reeve^[1]
[1]Bone Research Group, Cambridge, UK;^[2]University Hospital, Kuopio, Finland;^[3]District Hospital, Peterborough, UK

16:50

OP5

Chondrocytes in osteoarthritis de-differentiate to a progenitor-like intermediate before re-differentiating to a complex and mixed phenotype
MA Da Silva, HI Roach*
Bone & Joint Research Group, University of Southampton, General Hospital, Southampton, UK

16:55

OP6

Abstract withdrawn
 

17:00

OP7

Osteoblasts protect multiple myeloma cells from T-cell-induced apoptosis
RM Locklin*^[1], RGG Russell^[1], PI Croucher^[2], CM Edwards^[3]
[1]Institute of Musculoskeletal Sciences, Botnar Research Centre,
Nuffield Department of Orthopaedic Surgery, University of Oxford,Oxford, UK;^[2]Division of Clinical Sciences, University of Sheffield Medical School, Sheffield, UK;^[3]Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

17:05

OP8

The expression and regulation of Bim in osteoblasts undergoing growth factor withdrawal
M Liang*, RGG Russell, PA Hulley
Botnar Research Centre, Nuffield Dept of Orthopaedic Surgery, University of Oxford, UK

17:10

OP9

Novel control of GAG synthesis and chondrogenesis through selective regulation of UDPGD-mediated monosaccharide supply
CE Clarkin*, S Allen, BT Wheeler, CPD Wheeler-Jones, AA Pitsillides
The Royal Veterinary College, London, UK

17:15

OP10

The effect of tensile forces on the differentiation of mesenchymal stem cells
SB Mirza*,M Greenwood, G Blunn
Institute of Orthopaedics, University College London, UK

17:20

OP11

Genetic mutations in the RAS/RAF/MAPKinase pathway results in cherubism
BD Idowu*^[1], J Mangion^[2], RE Gale^[3], AM Flanagan^[4]
[1]Institute of Orthopaedics, UCL, London, UK;^[2]MRC Clincal Sciences Centre, Imperial College London, UK;^[3]Department of Haematology, UCL, London, UK;^[4]Institute of Orthopaedics, UCL, London, UK

17.30

Keynote Lecture

Chair: Professor C Duncan Rice
Principal & Vice-Chancellor of the University of Aberdeen

Ethical considerations and medical research: past, present and future
Neva Haites (Aberdeen, UK)
Head of the College of Life Sciences and Medicine

18:10

Crombie and Kings Hall residents – bus from AECC to Halls

19:20

Crombie and Kings Hall residents – bus to Beach Ballroom

19:45

Annual Dinner and Ceilidh in the Beach Ballroom