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Speaker Biographies
Mike Adams graduated in Natural Philosophy (Physics)
from Edinburgh University in 1975, and followed this with a PhD
in spinal mechanics from the University of Westminster. His publications
mostly concern the mechanical properties of the spine, intervertebral
disc (dys)function, and the mechanics of articular cartilage. In
2002 he published the book "Biomechanics of Back Pain"
with Nik Bogduk, Kim Burton, and Trish Dolan. He is currently Senior
Research Fellow in the Department of Anatomy at the University of
Bristol. Senior Lecturer in Geriatric Medicine at the University
of Southampton, Dr Anderson graduated from Edinburgh University
in 1986 and undertook training posts in Durham and Northumberland.
He developed an interest in osteoporosis while working for Dr Roger
Francis in Newcastle-upon-Tyne. He moved to his current post in
1995 and has spent ten years working on large clinical trials of
vitamin D and calcium supplementation for fracture prevention in
older people. Nick Bishop has been Professor of Paediatric Bone
Disease in Sheffield since 1998, having trained in Manchester and
Cambridge UK, and Montreal, Canada. His main research interests
are treatment strategies in osteogenesis imperfecta, other causes
of osteoporosis and recurrent fractures in children, and osteoclast
formation defects leading to osteoclast-poor osteopetrosis. Dr Lynda F Bonewald is a Curators' Professor and the Lee M. and William Lefkowitz Professor in the Department of Oral Biology and directs the Bone Biology Research Program. Dr. Bonewald has worked in the area of transforming growth factor beta and in the lipoxygenases but is probably best known for her research in osteocyte biology. Osteocytes are the most abundant cell in bone and may be responsible for sensing mechanical stress and signaling bone modeling and remodeling. She is Director of a program project entitled "The Effects of Mechanical Strain on Osteocyte Function". The program involves investigators at UMKC, KUMC, and UTHSC in San Antonio, Texas. This program project is composed of four projects and four cores to investigate the effects of mechanical strain on osteocyte function. Dr. Bonewald is presently the Chair of the Advocacy Committee for
ASBMR. She previously chaired the Board of Scientific Counselors
of the NIH's National Institute of Dental and Craniofacial Research
and is Past President of the Association for Biomolecular Resource
Facilities. She has also been a member of the Board of
Directors and the Public Affairs Executive Committee of the Federation
of American Societies for Experimental Biology. She serves
on the editorial boards for the Journal for Biomolecular Techniques
and now the Journal for Bone and Mineral Research and is
Associate Editor for Experimental Biology and Medicine. Cyrus Cooper is Professor of Rheumatology and Director of the MRC Epidemiology Resource Centre at the University of Southampton Medical School and Southampton General Hospital in the UK. Professor Cooper graduated from the University of Cambridge and St Bartholomew's Hospital, London in 1980, and completed his residency in 1985 at the Southampton University Hospitals. He then worked in the MRC Environmental Epidemiology Unit as an MRC Training Fellow, and at the University of Bristol as a Senior Registrar in Rheumatology. In 1990, he won an MRC Travelling Fellowship to the Mayo Clinic, USA, where he continued his research in osteoporosis. Cyrus Cooper returned to the UK in 1992 to take up a position as
Senior Lecturer in Rheumatology and MRC Senior Clinical Scientist.
He was promoted to the foundation Chair in Rheumatology at the University
of Southampton in 1997 while continuing as an MRC Senior Clinical
Scientist at the MRC Environmental Epidemiology Unit. In 2003,
he was appointed Director of the MRC Epidemiology Resource Centre,
University of Southampton Professor Eastell is Professor of Bone Metabolism at the University of Sheffield where he is also Deputy Director of the Division of Clinical Sciences (North). He is an Honorary Consultant Physician in metabolic bone disease at the Northern General Hospital, Sheffield. He qualified in medicine from Edinburgh in 1977. He trained at the Mayo Clinic under Dr B L Riggs for 5 years. He became a fellow of the Royal College of Physicians of London in 1996, an honorary fellow of the Royal College of Physicians of Ireland in 1998 and a Fellow of the Royal College of Physicians of Edinburgh, the Royal College of Pathology and the Academy of Medical Sciences in 2000. He is the head of the Academic Unit of Bone Metabolism Group and
has an active research group into the pathophysiology, diagnosis
and treatment of osteoporosis. He has published over 200 papers
on osteoporosis and related topics. In 1997, he was awarded Hospital
Doctor of the Year in the osteoporosis category, in 1998 he was
awarded the Corrigan Medal of the Royal College of Physicians of
Ireland, and in 2003, was part of the team awarded the Queen’s
Anniversary Award to the University of Sheffield for the Health
and Social Care of Older People. In 2004, he was awarded the Kohn
Foundation award from the National Osteoporosis Society and the
Society of Endocrinology Medal. He is on the editorial board of
Osteoporosis International, Osteoporosis Review, and Journal of
Clinical Endocrinology and Metabolism. He is the President of the
UK Bone Research Society and the President of the European Calcified
Tissue Society. He is Deputy Chairman of the Scientific Advisory
Group of the National Osteoporosis Society. He is a member of the
MRC Physiological Medicine and Infections Board. Alicia J El Haj received an MSc from Manchester and a PhD from
Aberdeen. Following two postdoctoral positions in Medical and Veterinary
Schools in Belfast and London, she took up a lectureship at Birmingham
in 1989. In 1997, she moved to Keele University to develop and expand
research in cell engineering as part of a new joint Medical School
between Manchester and Keele. Appointed to Research Director, she
was instrumental in forming and expanding the Institute for Science
and Technology in Medicine. The Institute, based on campus, at the
UHNS and the RJAH Orthopaedic Hospital has been rated 5A -
5* in the past 3 RAEs. The Institute research programme is at the
clinical interface, with ACI ongoing, and more stem cell treatments
planned in orthopaedic repair. Her research is in the field of bone
cell transduction of physical processes and translating this research
into connective tissue engineering and regenerative medicine funded
by the BBSRC, EPSRC, Welcome and EU with extensive publications
in the field. She is President of the UK Cell and Tissue Engineering
Society and Member of the IFMBE Working Group for Cellular Engineering. Christopher Evans holds the Robert Lovett Chair of Orthopaedic Surgery at Harvard Medical School where he is Director of the Center for Molecular Orthopaedics. He obtained a B.Sc. in Genetics and Microbiology, and a Ph.D. in Biochemistry from the University of Wales. After a period of post-doctoral research in the Department of Molecular Biology, Universite Libre de Bruxelles, Belgium, he came to the University of Pittsburgh Medical School ending up as the Henry Mankin Professor of Orthopaedic Surgery and Professor, Department of Molecular Genetics and Biochemistry. While at the University of Pittsburgh he obtained a MA in the History and Philosophy of Science. Dr Evans’s research interests focus on the application of gene therapy to treat disorders of bones and joints, a field he helped to found. Dr Evans is immediate Past-President of the Orthopaedic Research
Society and a Fellow of both the Royal Society of Chemistry and
the Royal College of Pathologists. Professor John Fisher is Deputy Vice Chancellor at the University of Leeds, Professor of Mechanical Engineering and Director of the Institute for Medical and Biological Engineering. The Institute has over 80 Post Doctoral Researchers and Doctoral research students, working in the field of tissue replacement and tissue engineering, and is supported by a current external research income of over £10 million. Professor Fisher has over 25 years experience in Medical Engineering
research, and has published over 350 journal papers in this field.
In the last 10 years his research has focused on wear, wear debris
of artificial joints. His laboratory has over 100 functional joint
simulation systems making it one of the largest research facilities
worldwide. More recently novel coupled biomechanical wear and biological
cell culture systems have been developed for pre clinical assessment
of the functional osteolytic potential of wear debris and joint
replacements. Current research also focuses on cartilage tissue
substitution, spine biomechanics and tissue engineering. The work
is supported by major collaborative programme funding from EPSRC
(Portfolio), NIH, EU and Industry with key international collaborations
in USA, Europe, China and Japan. Professor Kanis is director of the WHO Collaborating Centre for
Metabolic Bone Diseases at Sheffield. His interest in bone disease
covers basic, clinical research, health technology assessment, epidemiology
and health economics. He is an author of more than 500 scientific
publications and a Royal Society of Medicine Award Winner for his
Textbook on Osteoporosis. He is an Editor of Bone and sits on the
Editorial Board of several peer review journals. He is a long-standing
advisor for Government Departments and non-Governmental organisations
in several countries. He founded the International Osteoporosis
Foundation in 1988 and was Chairman of its Scientific Advisory Board
until 1998. He coordinates and participates in many international
research collaborations and has served on the project management
team of several EC-funded research awards (eg EVOS, EPOS). Richard Keen graduated from St Mary’s Hospital, London, UK. He is now Director of the Metabolic Bone Disease Unit at the Royal National Orthopaedic Hospital, Stanmore. Dr Keen also holds a senior lecturer appointment in rheumatology and metabolic bone diseases at the Institute of Orthopaedics and Musculoskeletal Sciences, University College London. Dr Keen heads a clinical research team, and is currently investigating potential new treatments for osteoporosis and other bone disorders. He is the chief investigator for the ZODIAC Study, which is assessing the role for bisphosphonates in the management of bone loss following spinal cord injury. He heads the VIDEO Study, an arc funded clinical trial examining the effect of vitamin D supplementation on symptomatic knee osteoarthritis. Dr Keen also works with the media and is often quoted on medical matters relating to osteoporosis and arthritis. Outside of medicine, Richard is married with three children. He
is a keen sportsman, with his loves being cricket and rugby. He
is a qualified mini/youth rugby coach, and his winter weekends are
often spent running around on a wet pitch somewhere in northwest
London. Dr John Loughlin completed his PhD in developmental biology at Leeds University in 1991, before commencing his postdoctoral research in the molecular genetic analysis of monogenic diseases of the extracellular matrix at Oxford University. His postdoctoral supervisor was Professor Bryan Sykes. In 1995 Dr Loughlin went on to establish his own group and to research the genetic basis of primary osteoarthritis (OA) at the Wellcome Trust Centre for Human Genetics, which was situated on the Nuffield Orthopaedic Centre site in Oxford. Publishing the first ever OA genome scan in 1999, Dr Loughlin and his colleagues now focus on an analysis of genes within refined regions of the genome. Dr. Loughlin’s continuing research aims to identify and understand the causal mutations that encode for OA susceptibility. In 1997 Dr Loughlin secured a Postdoctoral Research Fellowship from the Arthritis Research Campaign and in 2002 became a University Lecturer at Oxford. Dr Loughlin teaches medical genetics and supervises postgraduate and postdoctoral research scientists. He is an editorial board member of the Journal Musculoskeletal Sciences and he has given oral presentations of his group’s research at workshops, conferences and at Universities in Asia, Europe and North America. Dr Loughlin has published widely in a number of journals including
Nature Genetics, PNAS, BMJ and the American Journal of Human Genetics.
Present Post: Professor of Clinical Orthopaedics, UCL,
IOMS (since July 2005) Dr Stephen Minger is the Director of the Stem Cell Biology Laboratory and a Senior Lecturer in the new Wolfson Centre for Age Related Diseases at King's College London. Dr Minger received his PhD in Pathology (Neurosciences) in 1992 from the Albert Einstein College of Medicine. From 1992-1994, he was a post-doctoral fellow at the University of California, San Diego, where he first began to pursue research in neural stem cell biology. In 1995, Dr Minger was appointed an Assistant Professor in Neurology at The University of Kentucky Medical School. He moved his stem cell research programme to Guy’s Hospital in 1996 and was appointed a Lecturer in Biomolecular Sciences at King's College London in 1998. Over the last 15 years, his research group has worked with a wide range of somatic stem cell populations, as well as mouse and human embryonic stem (ES) cells. In 2002, together with Dr Susan Pickering and Professor Peter Braude, Dr Minger was awarded one of the first two licenses granted by the UK Human Fertilisation and Embryology Authority for the derivation of human ES cells. His group subsequently generated the first human embryonic stem cell line in the UK and was one of the first groups to deposit this into the UK Stem Cell Bank. They have gone on to generate three new human ES cell lines, including one that encodes the most common genetic mutation resulting in Cystic Fibrosis. In addition to the derivation of human ES cell lines, the Stem Cell Biology Laboratory is focused on the generation of a number of therapeutically relevant human somatic stem cell populations from embryonic stem cells. These include cardiac, vascular, retinal, and neural stem/progenitor cell populations, as well pancreatic ?-cells and oligodendrocyte progenitors. Dr Minger has established highly productive collaborations with a number of specialist groups in many areas of clinical interest throughout the UK, and is one of the co-organisers of the London Regenerative Medicine Network, a grass-roots, research-led organisation designed to stimulate clinical translation of cell- and gene-based therapies within London. He is also the Senior Editor of Regenerative Medicine, a new journal launched in Jan 2006 by Future Medicines. Dr Minger’s research is supported by the UK Medical Research
Council, The European Union, The Oliver Bird Foundation, The Wellcome
Trust, The UK Department of Trade and Industry, The Charitable Foundation
of Guy’s and St Thomas’ Hospitals, the BBSRC, and the
EPSRC amongst others. Dr John Newell-Price graduated in Medicine from Cambridge University
in 1990. He underwent training in Endocrinology at St Bartholomew’s
Hospital: from 1993 as a Lecturer, and was an MRC Training Fellow
from 1995-8 whilst doing his PhD. Since April 2000 he has been Senior
Lecturer in Endocrinology at University of Sheffield and Sheffield
Teaching Hospital Trust, and was elected FRCP in 2004. His specialist
clinical interest is in pituitary disease, Cushing’s syndrome
and neuroendocrine tumours, and basic science interest is in the
regulation of hormonal gene expression, and in particular epigenetic
mechanisms involved in gene silencing. Ian Reid MD is Professor of Medicine and Endocrinology at the University
of Auckland, New Zealand. His research interests include the pathogenesis
and management of osteoporosis, primary hyperparathyroidism &
Paget’s disease, and his research group has been active in
the identification of novel regulators of bone cell function. He
is President of the International Bone and Mineral Society, Secretary
of the Asian Pacific Osteoporosis Foundation, and a Fellow of the
Royal Society of New Zealand. Jonathan Tobias is a Reader in rheumatology at University of Bristol,
and consultant rheumatologist at Bristol Royal Infirmary, where
he has been based since 1995. His undergraduate studies in medicine
were at Cambridge University and London University from where he
qualified in 1984, followed by MD and PhD theses in bone biology
which he completed in 1990 and 1994 respectively, at St George’s
Hospital Medical School, London. His research, which has led to
49 original research papers and 18 book chapters and reviews, focuses
on the regulation of osteoblast activity by estrogen receptors and
other anabolic factors, the management of osteoporosis in adults,
and the factors which influence bone development in childhood. He
has extensive clinical experience in treating patients with osteoporosis,
and in running DXA-based osteoporosis diagnostic services. He serves
on the editorial board of Calcified Tissue International, the scientific
program committees of the American Society for Bone and Mineral
Research, the British Society for Rheumatology and National Osteoporosis
Society, and on the research committee of the Arthritis Research
Campaign. He is also treasurer of the Bone Research Society. Marian F. Young is Chief of the Molecular Biology of Bones and
Teeth Section in the Craniofacial and Skeletal Diseases Branch of
the National Institute of Dental and Craniofacial Research. She
received her BS from SUNY at Oneonta, NY (1976), and her PhD in
Developmental Biology from the Department of Genetics and Cell Biology
at the University of Connecticut (1981). After a fellowship in the
Lab of Developmental Biology and Anomalies at the NIDR (1981-1983)
Dr. Young headed a group in the Mineralized Tissue Research Branch
also at the NIDR where she began her investigations on the molecular
biology and function of ECM proteins in skeletal tissues. Her current
research focuses on regulation and function of small proteoglycans
in mineralized tissues and in their potential role in controlling
pathological skeletal conditions such as osteoporosis, osteoarthritis
and ectopic ossification. Dr. Young has published over 100 peer-reviewed
articles and numerous reviews and book chapters on the molecular
biology of ECM in mineralizing tissue. |
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