2004
Conference
Details
Programme
Abstracts
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Bone and Tooth Society Annual Meeting
Oxford, UK
29-30 June 2004
Poster Presentations
Odd-numbered posters, P1, P3, P5 etc,
to be manned between 15.00 and 16.00 on Tuesday 29 June. Even-numbered
posters, P2, P4, P6 etc, to be manned between 10.30 and 11.30 on Wednesday
30 June.
There will be an additional poster viewing
session between 19.00 and 20.00 on Tuesday 29 June.
P1 TNF-ALPHA RECEPTOR 1 CONTROLS ENDOCHONDRAL
BONE FORMATION IN ADULT MICE
I K Lukic[1], D Grcevic[2], N Kovacic[1],
V Katavic[1], A Marusic[1]. [1]Department
of Anatomy, Zagreb University School of Medicine, Zagreb, Croatia; [2]Department
of Physiology and Immunology, Zagreb University School of Medicine, Zagreb,
Croatia
P2 DENTIN MATRIX PROTEIN-1 AND BONE DEVELOPMENT
G Li[1], M Mushipe[1], H Rio[2], S Zhang[2],
L Bonewald[2] and J Q Feng[2]. [1]The Department
of Orthopaedic Surgery, Queen's University Belfast, Belfast, UK. [2]Oral
Biology, School of Dentistry, University of Missouri-Kansas City, Kansas City,
MO, USA
P3 COMBINED TREATMENTS OF BREAST CANCER
CELLS USING BISPHOSPHONATES AND DOXORUBICIN
H L Neville-Webbe, C A Evans, R E Coleman, I Holen. Clinical Oncology, Genomic
Medicine, University of Sheffield, UK
P4 ARE EPIGENETIC CHANGES IN DNA METHYLATIONS
A SIGNIFICANT FACTOR IN THE ALTERED GENE EXPRESSION OF OSTEOARTHRITIC
CHONDROCYTES?
S Inglis, R O C Oreffo, K A Partridge, N M P Clarke and H I Roach.Bone & Joint
Research Group, University of Southampton, CF86, General Hospital, Southampton
SO51 6BY, UK
P5 NE10790, A PHOSPHONOCARBOXYLATE ANALOGUE
OF RISEDRONATE, INDUCES HUMAN MYELOMA CELL APOPTOSIS IN VITRO
A J Roelofs[1], R G G Russell[1], F H Ebetino[2],
C M Shipman[1]. [1]University of Oxford, Oxford, UK; [2]Procter & Gamble
Pharmaceuticals, Cincinnati, Ohio, USA
P6 GROUP III METABOTROPIC GLUTAMATE RECEPTORS
ARE EXPRESSED IN BONE MARROW STROMAL CELLS AND ARE NEGATIVELY COUPLED
TO NITRIC OXIDE SYNTHASE
M A Foreman[1], Y Gu[2], S J Publicover[1]. [1]University
of Birmingham, Birmingham, UK; [2]University of Cambridge, Cambridge,
UK
P7 ROSUVASTATIN INHIBITS PROTEIN PRENYLATION
AND BONE RESORPTION BY OSTEOCLASTS IN VITRO
A Hughes, M J Rogers and J C Crockett..Bone Research Group, Institute of Medical
Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
P8 OSTEOCLASTIC CORTICAL EROSION OF THE
FEMORAL NECK IS POSITIVELY ASSOCIATED WITH SUB-PERIOSTEAL ALKALINE
PHOSPHATASE EXPRESSION IN ELDERLY FEMALE CASES OF HIP FRACTURE AND
CONTROLS
J Power[1], N Loveridge[1], A Lyon[1], N Rushton[2],
M Parker[3], J Reeve[1]. [1]Bone Research
Group (MRC), University of Cambridge, UK; [2]Orthopaedic Research
Unit, University of Cambridge, UK; [3]Peterborough District Hospital,
Peterborough, UK
P9 MODIFICATIONS TO THE PHOSPHONATE GROUPS
OF BISPHOSPHONATES AFFECTS THEIR POTENCY AND TARGET ENZYME SPECIFICITY
J A Rojas Navea[1], M J Rogers[1], F H Ebetino[2],
and F P Coxon[1]. [1]Bone Research Group, Institute of
Medical Sciences, University of Aberdeen AB25 2ZD, UK; [2]Procter & Gamble
Pharmaceuticals, Cincinnati OH, USA
P10 INNATE IMMUNE RESPONSES TO HUMAN MESENCHYMAL
STEM CELL IMPLANTATION IN IMMUNOCOMPROMISED MICE
Z Xia[1,2], P Taylor[3], S Gordon[3], Z Cui[2],
J T Triffitt[1]. [1]The Botnar Research Centre, Institute
of Musculoskeletal Sciences; [2]The Department of Engineering Sciences; [3]Sir
William Dunn School of Pathology, Oxford University, Oxford OX3 7LD
P11 IN VIVO BLOCKADE OF RETINOIC
ACID RECEPTOR SIGNALLING INHIBITS CELL PROLIFERATION AND THE DIFFERENTIATION
OF OSTEOCLASTS AND MATURATION OF CHONDROYTES IN REGENERATING DEER ANTLER
S P Allen, J S Price. Department of Veterinary Basic Sciences, The Royal Veterinary
College London, NW1 0TU
P12 MYELOMA CELLS CAN PROMOTE OSTEOCLASTIC
ACTIVITY RATHER THAN OSTEOCLAST RECRUITMENT IN VITRO; EVIDENCE FROM
THE 5T2MM MURINE MODEL OF MYELOMA
G S Mueller[1)], K Vanderkerken[2], R G G Russell[1],
P I Croucher[3]. [1]Botnar Research Centre, Nuffield
Department of Orthopaedic Surgery, University of Oxford, Oxford, UK; [2]Dept
of Hematology and Immunology, Free University Brussels, Brussels, Belgium; [3]Division
of Clinical Sciences, University of Sheffield School of Medicine, Sheffield,
UK
P13 THE d2 SUBUNIT OF THE VACUOLAR H+ATPASE
FORMS PART OF THE SPECIALIZED OSTEOCLAST AND RENAL PROTON PUMPS
A N Smith[1], S Bord[1], R S Al-Lamki[1],
F Jouret[2], K J Borthwick[1], D C Ireland[1],
O Devuyst[2], F E Karet[1]. [1]University
of Cambridge, Cambridge, UK; [2]Universit� Catholique de Louvain
Medical School, Brussels, Belgium
P14 SF-36 SCORE IS ASSOCIATED WITH FEMORAL
BONE MASS IN MIDDLE AGED UK MEN
E Dennison, H Syddall, H Gilbody, A Aihie Sayer, C Cooper. MRC Resource Centre,
Southampton SO16 6YD
P15 TEMPORAL AND SPATIAL DELIVERY OF CELLS
AND BIOMOLECULES USING BIOMINERALISED POLYSACCHARIDE CAPSULES FOR SKELETAL
TISSUE ENGINEERING
D Green[1], I Leveque[2], D Walsh[2], D Howard[1],
X Yang[1], K Partridge[1], S Mann[2] and R
O C Oreffo[1]. [1]University Orthopaedics, University
of Southampton, General Hospital, Southampton SO16 6YD, UK; [2]School
of Chemistry, University of Bristol, Bristol BS8 1TS, UK
P16 STIMULATION OF HUMAN BONE MARROW STROMAL
CELLS USING GROWTH FACTOR ENCAPSULATED CALCIUM CARBONATE POROUS MICROSPHERES
D Green[1], D Walsh[2], X Yang[1], S Mann[2],
R O C Oreffo[1]. [1]University Orthopaedics, University
of Southampton, General Hospital, Southampton, SO16 6YD, UK; [2] School
of Chemistry, University of Bristol, Bristol BS8 1TS, UK
P17 COL3A1: AN UNSUITABLE COMPARATOR FOR
MEASURING COLLAGEN MRNA EXPRESSION LEVELS IN BONE OF PATIENTS WITH
OSTEOGENESIS IMPERFECTA
A Afifi[1,2], R McMahon[1], A Dalton [1], N J Bishop[2],
P S Grabowski[2]. [1]North Trent Molecular Genetics Laboratory,
Sheffield, United Kingdom. [2]Academic Unit of Child Health, University
of Sheffield, United Kingdom
P18 A HISTOMORPHOMETRIC STUDY OF THE EFFECTS
OF STEROID TREATMENT ON THE CORTICAL BONE OF THE ILIAC CREST
S Vedi[1], S L Elkin[2], J E Compston[1]. [1]University
of Cambridge, Cambridge, UK; [2]Royal Brompton Hospital, London,
UK
P19 A LONGITUDINAL STUDY OF BONE-RELATED
BIOCHEMICAL VARIABLES ACROSS THE MENOPAUSE
B E C Nordin[1,2,4,5], J M Wishart[2], P M Clifton, R
McArthur[3], Scopacasa F[2], A G Need[1,2,4,5],
H A Morris[2,4], P D O'Loughlin[1], M Horowitz[2,5]. [1]Division
Clinical Biochemistry, Institute of Medical and Veterinary Science, Adelaide,
South Australia; [2]Department of Medicine, Royal Adelaide Hospital; [3]Human
Sciences and Nutrition, CSIRO; [4]Hanson Institute; [5]Endocrine
and Metabolic Unit, Royal Adelaide Hospital
P20 HYPOVITAMINOSIS D AMONG HEALTHY ADOLESCENT
GIRLS
S Crocombe[1], G Das[2], M McGrath[2], J L
Berry[3], M Z Mughal[1]. [1]Saint Mary's Hospital
for Women & Children, Manchester; [2]Central Manchester Primary
Care Trust; [3]University Department of Medicine, Manchester, UK
P21 REGULATION OF OSTEOCLASTOGENESIS BY
RHBMP-2 AND RHVEGF
C Wan and G Li.The Department of Trauma and Orthopaedic Surgery, Queen's University
Belfast, Musgrave Park Hospital, Belfast, BT9 7JB
P22 EFFECT OF TRANSFORMING GROWTH FACTOR-BETA
ON OSTEOCLAST PRECURSOR NFATC1 AND C-FOS EXPRESSION
A C Lovibond, T J Chambers, S W Fox..Department of Cellular and Molecular Medicine,
St George's Hospital, London, UK
P23 THE PRESENCE OF GLYCOSAMINOGLYCAN
EPITOPES IN CHONDROGENIC CULTURES OF STRO-1+ IMMUNO-SELECTED HUMAN
MARROW STROMAL CELLS
D Howard[1], C L Curtis[2], B Caterson[2],
R O C Oreffo[1]. [1]University Orthopaedics, University
of Southampton, Southampton, SO16 6YD, UK; [2]Connective Tissue
Biology Laboratories, Cardiff School of Biosciences, University of Cardiff,
Cardiff, CF10 3US, Wales, UK
P24 ADRENAL ANDROGENS REGULATE THE PRODUCTION
OF AUTOCRINE AND PARACRINE FACTORS IMPLICATED IN BOTH BONE RESORPTION
AND FORMATION IN A HUMAN OSTEOBLASTIC CELL LINE
G Harding[1], Y T Mak[1], B A J Evans[2],
J Cheung[1], I Fogelman[3], G Hampson[1]. [1]Department
of Chemical Pathology, St Thomas Hospital, London; [2]Department
of Child Health, University of Wales College of Medicine, Heath Park, Cardiff; [3]Osteoporosis
Screening Unit, 16th floor, Guy's Tower, Guy's Hospital
P25 HUMAN PHOSPHO1 DISPLAYS HIGH SPECIFIC
PHOSPHOETHANOLAMINE AND PHOSPHOCHOLINE PHOSPHATASE ACTIVITIES: A MEANS
OF GENERATING INORGANIC PHOSPHATE IN MINERALISING CELLS
S J Roberts[1], A J Stewart[1], P J Sadler[2],
C Farquharson[1]. [1]Roslin Institute, Roslin, Midlothian
EH25 9PS, UK; [2]School of Chemistry, The University of Edinburgh,
Edinburgh EH9 3JJ, UK
P26 CHONDROPTOSIS: A VARIANT OF APOPTOTIC
CELL DEATH IN CHONDROCYTES?
H I Roach[1], T Aigner[2], J B Kouri[3]. [1]Bone & Joint
Research Unit, Southampton, UK; [2]Dept. of Pathology, Nurnberg,
Germany; [3]Departamento de Patologia Experimental, Mexico DF
P27 HYDROSTATIC PRESSURE AND UHMWPE PARTICLES
MODULATE SYNTHESIS OF 1,25 DIHYDROXYVITAMIN D3 BY MACROPHAGES
C E Evans[1], S Mylchreest[1], A P Mee[1],
J L Berry[1], J G Andrew[2]. [1]University
of Manchester, Manchester, UK;[2]Salford Royal Hospital Trust, Salford,
UK
P28 MACROPHAGE ACTIVITY IN VITRO IS MODULATED
BY TNFA
C E Evans[1], S Mylchreest[1], A P Mee[1],
J L Berry[1], J G Andrew[2]. [1]University
of Manchester, Manchester, UK;[2]Salford Royal Hospital Trust, Salford,
UK
P29 EFFECTS OF VITAMIN K2 (MK-4) ON HUMAN
OSTEOBLAST PROLIFERATION AND DIFFERENTIATION
D C Ireland, S Bord, J E Compston.Cambridge University School of Clinical Medicine
P30 MATHEMATICAL MODEL SIMULATIONS SUPPORT
THE REGULATORY ROLE OF THE MATRIX IN BONE FORMATION VIA EMBEDDED MITOGENIC
FACTORS
M J Martin, J C Buckland-Wright..King's College, London, UK
P31 PATHOPHYSIOLOGY OF BONE LOSS AFTER
STROKE; A ROLE FOR VITAMIN D?
K E S Poole[1], C Rose[1], N Loveridge[1],
E A Warburton[2], J Reeve[1]. [1]MRC Bone
Research Group, University of Cambridge, Cambridge UK; [2]Stroke
Research Group, University of Cambridge, Cambridge UK
P32 BIOCHEMICAL BONE MARKERS IN COMBINATION
WITH BONE MINERAL DENSITY ARE USEFUL IN IDENTIFYING PATIENTS WITH GREATEST
FRACTURE RISK IN OSTEOPOROSIS
S Walker, G Li, S M Coward, M Finch..Trauma Research Group, Musculoskeletal
Education & Research Unit, Musgrave Park Hospital, Belfast, UK
P33 ULTRASOUND STIMULATES ATP RELEASE
FROM HUMAN OSTEOBLASTS IN VITRO
K A Buckley, M J Hayton, J P Dillon, J M Curran, J A Hunt, J A Gallagher. Human
Anatomy & Cell Biology and Clinical Engineering, University of Liverpool,
Liverpool, UK
P34 TYPES OF ACTIVITY AND BARRIERS TO
PARTICIPATION IN PHYSICAL ACTIVITY IN AN OLDER POPULATION WITH AND
WITHOUT MINIMAL TRAUMA FRACTURES
P A Turner. Social Futures Institute, University of Teesside, UK
P35 MORPHOLOGICAL CHECKING THE JAW DEFECT
AFTER ITS REPLACING BY THE MATERIAL 'LITAR'
S D Litvinov[1], P V Ivanov[2], A M Spiridonov[3],
RIb Rakhimov[4]. [1]Samara State Technical University,
Samara, Russia; [2]Penza State Medical Institute, Penza, Russia; [3]Head
State Health Office of the Samara State Region, Samara, Russia; [4]Emergence
Dental Service, Samara, Russia
P36 THE ADAPTATION OF THE PRE-PUBERTAL
SKELETON TO HIGH INTENSITY EXERCISE: A STUDY OF BONE AND MUSCLE GEOMETRY
K A Ward[1], J E Adams[1], S Roberts[2], R
L Ashby[1], M Z Mughal[3]. [1]Imaging Science & Biomedical
Engineering, University of Manchester, [2]CMMC Trust & University
of Manchester Biostatistics Group, [3]Paediatric Medicine, CMMC
Trust
P37 BISPHOSPHONATES INDUCE APOPTOSIS AND
INHIBIT ADHESION TO MINERALISED MATRIX IN LUNG CARCINOMA CELL LINES
C D Macdonald, L M Pickering, K W Colston, J L Mansi. St. George's Hospital
Medical School, London, UK
P38 INTERLEUKIN-1 BETA BLOCKS GLUCOCORTICOID
INHIBITION OF OSTEOPROTEGERIN PRODUCTION IN OSTEOBLASTIC CELLS
E L Humphrey, H L Smith, J H H Williams, M J Marshall. Charles Salt Centre,
Robert Jones and Agnus Hunt Orthopaedic Hospital, Oswestry, Shropshire, SY10
7AG, UK
P39 THE INHIBTION OF OSTEOPROTEGERIN PRODUCTION
IN HUMAN OSTEOBLAST-LIKE CELLS BY DISSOCIATED GLUCOCORTICOID ANALOGUES
E L Humphrey, H L Smith, J H H Williams, M J Marshall. Charles Salt Research
Centre, RJAH Orthopaedic Hospital, Oswestry, Shropshire, SY10 7AG, UK
P40 MEAT CONSUMPTION REDUCES THE RISK
OF NUTRITIONAL RICKETS AND OSTEOMALACIA
J L Berry[1], D Hole[2], J B Henderson[3],
M G Dunnigan[3]. [1]Vitamin D Research Group, University
Department of Medicine, Manchester Royal Infirmary, Manchester, M13 9WL; [2]Department
of Public Health Medicine, University of Glasgow, Glasgow, G12 8RZ; [3]University
Department of Human Nutrition, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK
P41 RESPONSES TO A SINGLE ORAL DOSE (50,000
IU) OF VITAMIN D2 IN OMNIVORE AND LACTOVEGETARIAN ASIAN AND WHITE WOMEN
J L Berry[1], S Mylchreest[1], M Davies[1],
E B Mawer[1], A P Mee[1], J Martin[1], D Hole[2] J
B Henderson[3] M G Dunnigan[3]. [1]Vitamin
D Research Group, University Department of Medicine, Manchester Royal Infirmary,
Manchester, M13 9WL; [2]Department of Public Health Medicine, University
of Glasgow, Glasgow, G12 8RZ; [3]University Department of Human
Nutrition, Glasgow Royal Infirmary, Glasgow, G31 2ER, UK
P42 BREAST CANCER CELL ADHESION IS INHIBITED
BY ZOLEDRONIC ACID BUT RESTORED BY CASPASE INHIBITION
L M Pickering, J L Mansi, K W Colston. St. George's Hospital Medical School,
London, UK
P43 THE LOSS OF BONE CAUSED BY OESTROGEN-DEFICIENCY
IS MEDIATED BY HYDROGEN PEROXIDE AND TNF-ALPHA EXPRESSION
C J Jagger, J M Lean, J T Davies, T J Chambers.Department of Cellular Pathology,
St George's Hospital Medical School, London
P44 THE GENERATION OF ANTIBODIES AGAINST
ADULT HUMAN MESENCHYMAL STEM CELLS BY PHAGE DISPLAY
J Letchford[1], A Cardwell[1], M Lee[2], J
N Beresford[1], M J Welham[1], M J Perry[2]. [1]University
of Bath, Bath, UK; [2]University of Bristol, Bristol, UK
P45 ROLE OF THE IIIC ISOFORM OF FGFR2
IN MURINE PALATOGENESIS
C A Perlyn[1], C Babbs[1], P Lonai[2], G M
Morris-Kay[1]. [1]University of Oxford, Department of
Human Anatomy, Oxford, UK; [2]Weizmann Institute of Science, Rehovot,
Israel
P46 BONE LOSS IN CHRONIC SPINAL CORD INJURY
J S Bubbear[1], A Gall[1], F R I Middleton[1],
V Shah[1], R W Keen[2]. [1]Royal National
Orthopaedic Hospital, Stanmore, Middx; [2]Department of Medicine,
University College London, London
P47 USE OF ALENDRONATE IN MANAGEMENT OF
OSTEOPOROSIS FOLLOWING SPINAL CORD INJURY: A REPORT OF 4 CASES
J S Bubbear[1], A Gall[2], F R I Middleton[2],
V Shah[1], R W Keen[3]. [1]Metabolic Unit,
Royal National Orthopaedic Hospital, Stanmore; [2]Spinal Injuries
Unit, Royal National Orthopaedic Hospital, Stanmore; [3]Department
of Medicine, University College London, London
P48 CIRCULATING CORTISONE, BIOCHEMICAL
BONE MARKERS AND BONE DENSITY
M S Cooper[1], H E Syddall[2], P J Wood[2],
P M Stewart[1], C Cooper[2], E M Dennison[2]. [1]University
of Birmingham, UK; [2]University of Southampton, UK
P49 CALCIUM SUPPLEMENTATION DOES NOT MODIFY
VITAMIN D STATUS IN 16-18 YEAR OLD BOYS
A M Willett, F Ginty, A Prentice. MRC Human Nutrition Research, Elsie Widdowson
Laboratory, Fulbourn Road, Cambridge, CB1 3AL, UK
P50 OSTEOBLAST CHARACTERISATION AND GENE
EXPRESSION DURING FAST GROWTH IN THE IMMATURE SKELETON
D H Murray, C Farquharson. Bone Biology Group, Roslin Institute, Roslin, Scotland,
UK
P51 TRANSIENT EXPOSURE TO HYPOXIA STIMULATES
ATP RELEASE FROM OSTEOBLASTS
I R Orriss, S Ranasinghe, G Knight, G Burnstock, T Arnett. Department of Anatomy
and Developmental Biology, University College London, London WC1E 6BT
P52 EFFECTS OF ZOLEDRONIC ACID ON THE
ADHESION AND INVASION OF PROSTATE CANCER CELLS AND THE INFLUENCE OF
THE SDF-1/CXCR4 CHEMOKINE PATHWAY
J P Coxon, R S Kirby, K W Colston. St. George's Hospital Medical School, London,
UK
P53 RELATIONSHIP BETWEEN STAGE OF OESTRUS
AND BONE CELL ACTIVITY IN THOROUGHBRED HORSES
P K Dyson[1], B F Jackson[2], R D Hattersley[2],
H Kelly[2], D U Pfeiffer[1], Price J S[2]. [1]Department
of Veterinary Clinical Sciences and [2]Department of Veterinary
Basic Sciences, The Royal Veterinary College, London NW1 0TU
P55 CALCIUM PHOSPHATE COATED CONSTRUCTS
FOR BONE TISSUE ENGINEERING
C Choong[1,2], Z F Cui[1], J Triffitt[2]. [1]Department
of Engineering Science, University of Oxford, UK; [2]Nuffield Department
of Orthopaedic Surgery, University of Oxford, UK
P56 INCREASED OSTEOBLASTIC DIFFERENTIATION
IN CULTURED MARROW CELLS AFTER BLOOD LOSS OR SURGERY
S Odoi, J H Burford, R L Souza, L K Parry, T M Skerry. The Royal Veterinary
College, London, UK
P57 BOVINE BONE SUBSTITUTE IN REVISION
KNEE ARTHROPLASTY
A Lakdawala , S Muquit , M Y El-Zebdeh , R R Gadel Rab. Newham General Hospital,
London, UK
P58 ABNORMAL SEPTOCLASTS AT THE CHONDROOSSEOUS
JUNCTION IN THE TL RAT ARE NORMALISED FOLLOWING CSF-1 TREATMENT
A Gartland[1,2], A Mason-Savas[2], C MacKay[2], E R Lee[3],
J Mort[3], P R Odgren[2], S C Marks Jr[2]. [1]The
University of Liverpool, Liverpool, UK; [2]Univ. of Massachusetts
Medical School, MA, USA; [3]Shriner's Hospital for Children and
McGill University, Montreal, Quebec, Canada
P59 A ROLE FOR THE CANONICAL WNT SIGNALLING
PATHWAY IN THE REGENERATING DEER ANTLER
J G Mount, S P Allen, T AlThnaian, J S Price. Department of Veterinary Basic
Sciences, The Royal Veterinary College London, NW1 0TU
P60 CANONICAL WNT SIGNALLING REGULATES
THE DIFFERENTIATION OF OSTEOCLASTS FROM REGENERATING DEER ANTLERS
T Althnaian, S P Allen, M Muzylak, J S Price. Department of Veterinary Basic
Sciences, The Royal Veterinary College London, NW1 0TU
P61 A MODULATORY ROLE FOR ADENOSINE IN
BONE CELLS?
B A J Evans[1], C Elford[1], J Ham[2]. [1]Department
of Child Health and [2]Department of Medicine, University of Wales
College of Medicine, Heath Park, Cardiff CF14 4XN, UK
P62 LYMPHOBLASTOID CELLS IN FIBRODYSPLASIA
OSSIFICANS PROGRESSIVA - DO THEY PLAY A ROLE?
T J Cohen, J T Triffitt. University of Oxford Institute of Musculoskeletal
Sciences, Nuffield Orthopaedic Centre, Oxford
P63 STATINS: POTENTIAL CARTILAGE ANABOLICS?
I Gennero[1], S C Dickinson[2], T J Smis[2],
P Hulley[1], A P Hollander[2], R G G Russell[1]. [1]University
of Oxford, Oxford, UK; [2]University of Bristol, Bristol, UK.
P64 THE VALUE OF TOTAL BODY BONE MINERAL
DENSITY FOR THE ASSESSMENT OF FRACTURE RISK IN TRANSPLANT RECIPIENTS
M C Casey, E Thornton, N Maher, C Walsh C Cunningham, D Coakley, J B Walsh.
Falls and Osteoporosis Unit, St James Hospital, Dublin, Ireland
P65 HUMAN OSTEOBLAST-LIKE CELLS HAVE HIGH
DENSITY MAXI-K CHANNELS
K T Wann[1], N Henney[1], I Prajerova[1],
U V Boolaky[1], B A J Evans[2]. [1]Welsh School
of Pharmacy, Redwood Building, King Edward VII Ave, Cardiff, CF10 3XF, UK; [2]Department
of Child Health, University of Wales College of Medicine, Heath Park, Cardiff
CF14 4XN UK
P66 SARCOMA-ASSOCIATED MACROPHAGES DIFFERENTIATE
INTO OSTEOCLASTIC BONE-RESORBING CELLS
Y S Lau[1], J Edwards[1], A. Sabokbar[1],
C L M H Gibbons[2], H Giele[2], N.A. Athanasou[1]. [1]Department
of Pathology, Nuffield Department of Orthopaedic Surgery, University of Oxford; [2]Nuffield
Department of Orthopaedic Surgery, Nuffield Orthopaedic Centre, Oxford
P67 SYNOVIAL FLUID PROMOTES MACROPHAGE
AND OSTEOCLAST FORMATION IN INFLAMMATORY ARTHRITIS
I Adamopoulos, L Danks, A Sabokbar, A Carr, B P Wordsworth, N A Athanasou.Institute
of Musculoskeletal Sciences, University of Oxford, OX3 7LD, UK
P68 LIGHT, A TNF-SUPERFAMILY MEMBER, INDUCES
OSTEOCLAST FORMATION IN VITRO; A NOVEL MEDIATOR OF BONE RESORPTION?
J R Edwards, S G Sun, C M Shipman, N A Athanasou, A Sabokbar. Nuffield Department
of Orthopaedic Surgery, University of Oxford, UK
P69 RELATIONSHIP BETWEEN OSTEOPENIA AND
LUMBAR INTERVERTEBRAL DISC DEGENERATION IN OVARIECTOMIZED RATS
T Wang[1], L Zhang[2], C Huang[3],A G Cheng[2],G.T
Dang[1]. [1]Department of Orthopaedic Surgery, Peking
University Third Hospital, Beijing; [2]Department of Orthopedic
Surgery, Affiliated Hospital, North China Coal Medical College; [3]Department
of Orthopaedic Surgery,Yan Tai Shan Hospital
P70 THE EFFECT OF MECHANICAL STIMULATION
ON OSTEOCYTE VIABILITY IN BONE
V Mann[1], M Kratz[2], D B Jones[2], B S Noble[1]. [1]The
Scottish Mechanotransduction Consortium, University of Edinburgh Medical School, [2]Dept.
Experimental Orthopaedics and Biomechanics, Philipps University Marburg
P71 A SELECTIVE ESTROGEN RECEPTOR MODULATOR
(SERM) INHIBITS OSTEOCYTE APOPTOSIS DURING ESTROGEN LOSS. IMPLICATIONS
FOR BONE QUALITY MAINTENANCE
S Collishaw[1], J Mosley[1], C Taylor[1],
J Reeve[2], B S Noble[1]. [1]Edinburgh University,
Edinburgh, United Kingdom, [2]Cambridge University, Cambridge, UK
P72 THE ANTI-OXIDANT EFFECTS OF ESTROGEN
AND ESTROGENIC DERIVATIVES IN THE PROTECTION OF OSTEOCYTES FROM OXIDATIVE
STRESS INDUCED CELL DEATH IN VITRO
V Mann, C Huber, G Kogianni, C Towell, B S Noble. The Scottish Mechanotransduction
Consortium, University of Edinburgh Medical School, EH8 9AG
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