Tuesday 29th June

9.30-10.30

Registration / coffee

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Mini Symposium: WNT signalling in bone and cartilage
Chairmen: Tim Chambers/Jack Martin

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10.30

IS2
WNT/�-CATENIN SIGNALING PROMOTES OSTEOBLAST ACTIVITY AND BONE FORMATION
Georges Rawadi (Paris, France)

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11.00-12.24

Oral communications
Chairmen: Tim Chambers/Jack Martin

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11.00

OC1
(Bone and Tooth Society Scholarship) INFLUENCE OF LRP5 GENE POLYMORPHISMS ON THE NORMAL VARIATION OF BONE MINERAL DENSITY
M A Koay^[1], E L Duncan^[2], S H Ralston^[3], J E Compston^[4], C Cooper^[5], R Keen^[6], B L Langdahl^[7], A MacLelland^[8], J O'Riordan^[6], H A Pols^[9], D M Reid^[3], A G Uitterlinden^[9], J A H Wass^[2], M A Brown^[1]. ^[1]Institute of Musculoskeletal Sciences, University of Oxford, UK; ^[2]Metabolic Bone Unit, Nuffield Orthopaedic Centre, Oxford, UK; ^[3]Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, ^[4]Clinical Medicine, University of Cambridge, Cambridge, UK; ^[5]MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK; ^[6]Clinical Medicine, Royal National Orthopaedic Hospital, Middlesex, UK; ^[7]Department of Endocrinology, Aarhus Amtssygehus, Aarhus, Denmark; ^[8]Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK; ^[9]Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, Netherlands

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11.12

OC2
RAPID INHIBITORY EFFECTS OF GLUCOCORTICOIDS ON ERK ACTIVITY AND OSTEOBLAST PROLIFERATION OCCUR VIA TRANSCRIPTIONAL UPREGULATION OF MKP-1
K Horsch^[1], H de Wet^[1], C R Langeveldt^[1], F S Hough^[1], J M Burrin^[2], J Cunningham^[2], P A Hulley^[1,3]. ^[1]Dept Internal Medicine, Faculty of Health Sciences, University of Stellenbosch, Cape Town, South Africa; ^[2]Molecular Endocrinology, St Barts Hospital, London, UK; ^[3]Institute of Musculoskeletal Sciences, University of Oxford, UK

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11.24

OC3
PRENATAL GLUCOCORTICOID EXPOSURE RETARDS BONE GROWTH IN MICE AND IS ASSOCIATED WITH RAISED SERUM IGF-1
T Mushtaq^[1], C Farquharson^[1], M Nyirenda^[2], E Seawright^[1], J R Seckl^[2], S F Ahmed^[3]. ^[1]Bone Biology Group, Roslin Institute, Edinburgh; ^[2]Endocrinology Unit, Edinburgh University, Western General Hospital, Edinburgh; ^[3]Bone and Endocrine Research Group, Royal Hospital for Sick Children, Glasgow

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11.36

OC4
ACTIVATORS OF PPAR ALPHA AND DELTA INCREASE BONE DENSITY IN INTACT MALE RATS
K Still^[1], J Clarke^[1], A Scutt^[1], M Perry^[2]. ^[1]University of Sheffield; ^[2]University of Bristol

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11.48

OC5
OSTEOBLAST FUNCTION IS INHIBITED COOPERATIVELY BY ACIDOSIS AND HYPOXIA
A Brandao-Burch, J C Utting, I R Orriss, T R Arnett. Department of Anatomy & Developmental Biology, University College London, London WC1E 6BT, UK

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12.00

OC6
CHARACTERISATION OF OSTEOCRIN, A NOVEL BONE-SPECIFIC PROTEIN, IN HUMAN TISSUE
S Bord^[1], D C Ireland^[1], P Moffatt^[2], G P Thomas^[2], J E Compston^[1].� ^[1]Cambridge University School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK. ^[2]Phenogene Therapeutics Inc, Montreal, Quebec, Canada

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12.12

OC7
A NOVEL DUAL FLUORESCENCE ASSAY SHOWS THE PREFERENTIAL ADHERENCE OF OSTEOBLASTS TO RESORPTION SURFACES
P Untiveros, M H Helfrich and R J van't Hof. University of Aberdeen, Aberdeen, UK

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12.30

IS2
ATF4 AS A REGULATOR OF BONE FORMATION
Gerard Karsenty (Houston TX, USA)

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13.00-14.00

Lunch

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Mini Symposium: Genetics of skeletal disorders
Chairmen: Tim Chambers/Jack Martin

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14.00

IS3
GENETIC FACTORS AND OSTEOPOROSIS
Matthew Brown (Oxford, UK)

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14.30

IS4
FGF SIGNALLING IN SKELETAL DEVELOPMENT
Gillian Morriss-Kay (Oxford, UK)

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15.00-16.00

Poster viewing / coffee

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Mini Symposium: The immune system and bone
Chairmen: Bob Marcus/Peter Selby

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16.00

IS5
THE IMMUNE SYSTEM AND BONE REMODELLING
Matthew Gillespie(Fitzroy, Australia)

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16.30

IS6
MOUSE MODELS TO STUDY INTERACTIONS BETWEEN THE IMMUNE SYSTEM AND BONE IN VIVO
Ana Marusic (Zagreb, Croatia)

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17.00-18.00

Oral communications
Chairmen: Bob Marcus/Peter Selby

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17.00

OC8
MID FEMORAL NECK CORTICAL MORPHOLOGY CHANGES WITH AGE
P M Mayhew^[1], C D L Thomas^[2], N Loveridge^[1], J Clement^[2], J Reeve ^[1]. ^[1]Bone Research Group (MRC), Department of Medicine, University of Cambridge; ^[2]School of Dental Science, University of Melbourne

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17.12

OC9
IS DIVERSITY MORE IMPORTANT THAN QUANTITY OF PHYSICAL ACTIVITY IN MAINTAINING THE FRACTURE RESISTANCE OF THE PROXIMAL FEMUR?
S Kaptoge, N Dalzell, R W Jakes, N Wareham, K T Khaw, N Loveridge, J Reeve. University of Cambridge, Cambridge, UK

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17.24

OC10
FRACTURES AND ALL-CAUSE MORTALITY IN A POPULATION SAMPLE OF ELDERLY WOMEN; OBSERVATIONS FROM THE MRC HIP STUDY
E V McCloskey^[1], S Vasireddy^[1], J Cliffe^[1], L Reaney^[1], D Charlesworth^[1], C McGurk^[1], T Jalava^[2], M N C Beneton^[1], J A Kanis^[1]. ^[1]University of Sheffield, Sheffield, UK; ^[2]Schering Oy, Helsinki, Finland

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17.36

OC11
UMBILICAL CORD CALCIUM AND MATERNAL VITAMIN D STATUS PREDICT DIFFERENT LUMBAR SPINE BONE PARAMETERS IN THE OFFSPRING AT 9 YEARS
N C W Harvey^[1], M K Javaid^[1], P Taylor^[2], S R Crozier^[1], C R Gale^[1], E M Dennison^[1], K M Godfrey^[1], C Cooper^[1]. ^[1]MRC EEU, University of Southampton, Southampton, UK; ^[2]Medical Physics and Bioengineering, Southampton General Hospital, Southampton, UK

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17.48

OC12
ANNUAL INTRAMUSCULAR VITAMIN D AND FRACTURE IN THE ELDERLY
H Smith^[1], F Anderson^[2], H Raphael^[1], S Crozier^[3], C Cooper^[3]. ^[1]Primary Medical Care, University of Southampton, UK; ^[2]Department of Geriatric Medicine, Southampton General Hospital, UK; ^[3]MRC Environmental Epidemiology Unit, University of Southampton, UK

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19.00-20.00

Reception and poster viewing

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20.00

Annual Dinner

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