Tuesday 29th June

9.30-10.30

Registration / coffee

Mini Symposium: WNT signalling in bone and cartilage
Chairmen: Tim Chambers/Jack Martin

10.30

IS2
WNT/�-CATENIN SIGNALING PROMOTES OSTEOBLAST ACTIVITY AND BONE FORMATION
Georges Rawadi (Paris, France)

11.00-12.24

Oral communications
Chairmen: Tim Chambers/Jack Martin

11.00

OC1
(Bone and Tooth Society Scholarship) INFLUENCE OF LRP5 GENE POLYMORPHISMS ON THE NORMAL VARIATION OF BONE MINERAL DENSITY
M A Koay^[1], E L Duncan^[2], S H Ralston^[3], J E Compston^[4], C Cooper^[5], R Keen^[6], B L Langdahl^[7], A MacLelland^[8], J O'Riordan^[6], H A Pols^[9], D M Reid^[3], A G Uitterlinden^[9], J A H Wass^[2], M A Brown^[1]. ^[1]Institute of Musculoskeletal Sciences, University of Oxford, UK; ^[2]Metabolic Bone Unit, Nuffield Orthopaedic Centre, Oxford, UK; ^[3]Institute of Medical Sciences, University of Aberdeen Medical School, Aberdeen, ^[4]Clinical Medicine, University of Cambridge, Cambridge, UK; ^[5]MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, UK; ^[6]Clinical Medicine, Royal National Orthopaedic Hospital, Middlesex, UK; ^[7]Department of Endocrinology, Aarhus Amtssygehus, Aarhus, Denmark; ^[8]Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK; ^[9]Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, Netherlands

11.12

OC2
RAPID INHIBITORY EFFECTS OF GLUCOCORTICOIDS ON ERK ACTIVITY AND OSTEOBLAST PROLIFERATION OCCUR VIA TRANSCRIPTIONAL UPREGULATION OF MKP-1
K Horsch^[1], H de Wet^[1], C R Langeveldt^[1], F S Hough^[1], J M Burrin^[2], J Cunningham^[2], P A Hulley^[1,3]. ^[1]Dept Internal Medicine, Faculty of Health Sciences, University of Stellenbosch, Cape Town, South Africa; ^[2]Molecular Endocrinology, St Barts Hospital, London, UK; ^[3]Institute of Musculoskeletal Sciences, University of Oxford, UK

11.24

OC3
PRENATAL GLUCOCORTICOID EXPOSURE RETARDS BONE GROWTH IN MICE AND IS ASSOCIATED WITH RAISED SERUM IGF-1
T Mushtaq^[1], C Farquharson^[1], M Nyirenda^[2], E Seawright^[1], J R Seckl^[2], S F Ahmed^[3]. ^[1]Bone Biology Group, Roslin Institute, Edinburgh; ^[2]Endocrinology Unit, Edinburgh University, Western General Hospital, Edinburgh; ^[3]Bone and Endocrine Research Group, Royal Hospital for Sick Children, Glasgow

11.36

OC4
ACTIVATORS OF PPAR ALPHA AND DELTA INCREASE BONE DENSITY IN INTACT MALE RATS
K Still^[1], J Clarke^[1], A Scutt^[1], M Perry^[2]. ^[1]University of Sheffield; ^[2]University of Bristol

11.48

OC5
OSTEOBLAST FUNCTION IS INHIBITED COOPERATIVELY BY ACIDOSIS AND HYPOXIA
A Brandao-Burch, J C Utting, I R Orriss, T R Arnett. Department of Anatomy & Developmental Biology, University College London, London WC1E 6BT, UK

12.00

OC6
CHARACTERISATION OF OSTEOCRIN, A NOVEL BONE-SPECIFIC PROTEIN, IN HUMAN TISSUE
S Bord^[1], D C Ireland^[1], P Moffatt^[2], G P Thomas^[2], J E Compston^[1].  ^[1]Cambridge University School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK. ^[2]Phenogene Therapeutics Inc, Montreal, Quebec, Canada

12.12

OC7
A NOVEL DUAL FLUORESCENCE ASSAY SHOWS THE PREFERENTIAL ADHERENCE OF OSTEOBLASTS TO RESORPTION SURFACES
P Untiveros, M H Helfrich and R J van't Hof. University of Aberdeen, Aberdeen, UK

12.30

IS2
ATF4 AS A REGULATOR OF BONE FORMATION
Gerard Karsenty (Houston TX, USA)

13.00-14.00

Lunch

Mini Symposium: Genetics of skeletal disorders
Chairmen: Tim Chambers/Jack Martin

14.00

IS3
GENETIC FACTORS AND OSTEOPOROSIS
Matthew Brown (Oxford, UK)

14.30

IS4
FGF SIGNALLING IN SKELETAL DEVELOPMENT
Gillian Morriss-Kay (Oxford, UK)

15.00-16.00

Poster viewing / coffee

Mini Symposium: The immune system and bone
Chairmen: Bob Marcus/Peter Selby

16.00

IS5
THE IMMUNE SYSTEM AND BONE REMODELLING
Matthew Gillespie(Fitzroy, Australia)

16.30

IS6
MOUSE MODELS TO STUDY INTERACTIONS BETWEEN THE IMMUNE SYSTEM AND BONE IN VIVO
Ana Marusic (Zagreb, Croatia)

17.00-18.00

Oral communications
Chairmen: Bob Marcus/Peter Selby

17.00

OC8
MID FEMORAL NECK CORTICAL MORPHOLOGY CHANGES WITH AGE
P M Mayhew^[1], C D L Thomas^[2], N Loveridge^[1], J Clement^[2], J Reeve ^[1]. ^[1]Bone Research Group (MRC), Department of Medicine, University of Cambridge; ^[2]School of Dental Science, University of Melbourne

17.12

OC9
IS DIVERSITY MORE IMPORTANT THAN QUANTITY OF PHYSICAL ACTIVITY IN MAINTAINING THE FRACTURE RESISTANCE OF THE PROXIMAL FEMUR?
S Kaptoge, N Dalzell, R W Jakes, N Wareham, K T Khaw, N Loveridge, J Reeve. University of Cambridge, Cambridge, UK

17.24

OC10
FRACTURES AND ALL-CAUSE MORTALITY IN A POPULATION SAMPLE OF ELDERLY WOMEN; OBSERVATIONS FROM THE MRC HIP STUDY
E V McCloskey^[1], S Vasireddy^[1], J Cliffe^[1], L Reaney^[1], D Charlesworth^[1], C McGurk^[1], T Jalava^[2], M N C Beneton^[1], J A Kanis^[1]. ^[1]University of Sheffield, Sheffield, UK; ^[2]Schering Oy, Helsinki, Finland

17.36

OC11
UMBILICAL CORD CALCIUM AND MATERNAL VITAMIN D STATUS PREDICT DIFFERENT LUMBAR SPINE BONE PARAMETERS IN THE OFFSPRING AT 9 YEARS
N C W Harvey^[1], M K Javaid^[1], P Taylor^[2], S R Crozier^[1], C R Gale^[1], E M Dennison^[1], K M Godfrey^[1], C Cooper^[1]. ^[1]MRC EEU, University of Southampton, Southampton, UK; ^[2]Medical Physics and Bioengineering, Southampton General Hospital, Southampton, UK

17.48

OC12
ANNUAL INTRAMUSCULAR VITAMIN D AND FRACTURE IN THE ELDERLY
H Smith^[1], F Anderson^[2], H Raphael^[1], S Crozier^[3], C Cooper^[3]. ^[1]Primary Medical Care, University of Southampton, UK; ^[2]Department of Geriatric Medicine, Southampton General Hospital, UK; ^[3]MRC Environmental Epidemiology Unit, University of Southampton, UK

19.00-20.00

Reception and poster viewing

20.00

Annual Dinner