Tuesday 5th July

08:00

Buses from Chamberlain Hall to meeting

08:30-09:30

Symposium: Local regulators of bone metabolism

Chairmen: Michael Parfitt (Boston MA, USA)/Richard Oreffo (Southampton, UK)

08:30

IS7

WHAT DO BONE LINING CELLS REALLY DO?

Vincent Everts (Amsterdam,The Netherlands)

09:00

IS8

OSTEOCYTE CONTROL OF OSTEOBLAST FUNCTION

Clemens L�wik (Leiden,The Netherlands)

09:30-10:30

Oral communications

Chairmen: Bronwen Evans (Cardiff, UK)/Agi Grigoriadis (London, UK)

09:30

OC13

SCLEROSTIN EXPRESSION BY OSTEOCYTES IS A DELAYED EVENT; IMPLICATIONS FOR THE CONTROL OF BONE FORMATION

K E S Poole (Cambridge, UK)

09:42

OC14

OSTEOBLAST AND CHONDROCYTE MATRIX VESICLES CONTAIN HOSPHO1: EVIDENCE FOR ITS ROLE IN MINERAL FORMATION

S J Roberts (Roslin, UK)

09:54

OC15

THE CIRCADIAN RHYTHM OF OSTEOPROTEGERIN AND ITS ASSOCIATION WITH PARATHYROID HORMONE SECRETION IN ELDERLY MEN AND WOMEN

F Joseph (Liverpool, UK)

10:06

OC16

BISPHOSPHONATES PREVENT ADHESION OF BREAST CANCER CELLS TO BONE IN VITRO BY INHIBITING PROTEIN PRENYLATION

S Garrioch (Aberdeen, UK)

10:18

OC17

APOMINE, AN INHIBITOR OF HMG-COA-REDUCTASE, DOES NOT ACT BY INHIBITING PROTEIN PRENYLATION IN HUMAN MYELOMA CELLS IN VITRO

A J Roelofs (Oxford, UK)

10:30-11:30

Poster viewing / coffee

11:30-12:30

Poster discussion

Chairmen: Juliet Compston (Cambridge, UK)/Clemens L�wik (Leiden,The Netherlands)

11:30

P1

LOCALISATION OF HIF-2ALPHA TO SPECIFIC MATURATIONAL ZONES OF BOTH GROWTH PLATE AND ARTICULAR CARTILAGE

A J Stewart (Roslin, UK)

11:35

P2

THE RESTRICTED POTENTIAL FOR RECOVERY OF GROWTH PLATE CHONDROGENESIS AND LONGITUDINAL BONE GROWTH FOLLOWING EXPOSURE TO PROINFLAMMATORY CYTOKINES

V E MacRae (Glasgow and Roslin, UK)

11:40

P3

OSTEOBLAST CELL CYCLE REGULATION DURING DIFFERENTIATION DIFFERS FROM THAT OF EXPONENTIAL GROWTH: THE ROLE OF P27 AND CYCLIN D3

A Sunters (London, UK)

11:45

P4

INTRAUTERINE PROGRAMMING OF MESENCHYMAL STEM CELL ACTIVITY

S A Lanham (Southampton, UK)

11:50

P5

DIFFERENCES IN OESTROGEN RECEPTOR TRAFFICKING BETWEEN BONE AND MAMMARY CELLS

B S Maru (Bristol, UK)

11:55

P6

THE ROLE OF CALCIUM IONS IN THE CELLULAR UPTAKE OF BISPHOSPHONATE DRUGS

D M Scheven (Aberdeen, UK)

12:00

P7

STUDIES OF THE EXPRESSION IN HUMAN DUODENUM OF THE CALCIUM TRANSPORTER TRPV6 AND THE RELATIONSHIP TO VITAMIN D, AGE, SEX AND BONE MINERAL DENSITY

J R F Walters (London, UK)

12:05

P8

OSTEOCLAST FORMATION POTENTIAL IS INCREASED AT TIMES OF PULMONARY INFECTION IN ADULTS WITH CYSTIC FIBROSIS

E Shead (Cambridge, UK)

12:10

P9

LARGE POPULATION-BASED GEOGRAPHIC VARIATIONS IN DXA BMD IN MEN AND WOMEN ACROSS EUROPE. RESULTS FROM THE NETWORK FOR MALE OSTEOPOROSIS (NEMO) STUDY

S Kaptoge (Cambridge, UK)

12:15

P10

AUTOCRINE REGULATION OF GLUCOCORTICOIDS BY 11 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1: A MECHANISM FOR TISSUE-SPECIFIC REGULATION OF INFLAMMATION

R S Hardy (Birmingham, UK)

12:30-13:15

Awards

Bone and Tooth Society AGM (members)

Lunch

13:15-14:15

Symposium: Nutrition and bone

Chairmen: Roger Francis (Newcastle upon Tyne, UK)/David Reid (Aberdeen, UK)

13:15

IS9

CALCIUM AND BONE: HOW MUCH AND WHEN?

Ann Prentice (Cambridge, UK)

13:45

IS10

FRUIT AND VEGETABLES IN BONE HEALTH

Helen MacDonald (Aberdeen, UK)

14:15-15:00

Oral communications – clinical

Chairmen: Richard Keen (London, UK)/Larry Raisz (Farmington, USA)

14:15

OC18

FAMILIAL HYPOMAGNESAEMIA-HYPERCALCIURIA AND NEPHROCALCINOSIS IN 2 SIBLINGS : 2 NOVEL HETEROZYGOUS MUTATIONS IN THE GENE ENCODING CLAUDIN-16

G Hampson (London, UK)

14:30

OC19

A RANDOMISED CONTROLLED TRIAL (RCT) OF OSTEOPOROSIS SCREENING: LONG TERM EFFECTS ON USE OF MEDICATION AND FRACTURE RISK

R J Barr (Aberdeen, UK)

14:45

OC20

THE RECORD TRIAL OF CALCIUM AND/OR VITAMIN D IN THE SECONDARY PREVENTION OF OSTEOPOROTIC FRACTURES

A M Grant (Aberdeen, UK)

15:00-15:20

Tea

15:20-16:50

Clinical Symposium

Chairmen: Richard Eastell (Sheffield, UK)/Neil Gittoes (Birmingham, UK)

15:20

IS11

MEDICAL APPROACHES TO HYPERPARATHYROIDISM

John Bilezikian (New York, USA)

15:50

IS12

AETIOLOGY OF PAGET'S DISEASE OF BONE AND SUMMARY OF CURRENT TREATMENT GUIDELINES

Fred Singer (Los Angeles, USA)

16:20

IS13

UPDATE ON TREATMENTS FOR OSTEOPOROSIS

Michael McClung (Portland, USA)

16:50

End of Meeting