TUESDAY 3 JULY 

08:55

Crombie and Kings Hall residents - bus to AECC

09:30

Coffee, registration, poster hanging

10:25

Opening and welcome

Chair: David Reid (Aberdeen, UK)

Stephen Logan
Senior Vice-Principal, University of Aberdeen

Bone pain

Chairs: Steven Goldring (New York, USA) and Jonathan Reeve (Cambridge, UK)

10:30

IS1

Acid and bone
Tim Arnett (London, UK)

11:00

IS2

The role of the endocannabinoid system in pain modulation
Ruth Ross (Aberdeen, UK)

11:30

IS3

Cannabinoids and bone
Rob van t’Hof (Edinburgh, UK)

12:00

Oral communications 1

Chairs: Tim Arnett (London, UK) and Miep Helfrich (Aberdeen, UK)

12:00

OC1

The endocannabinoids 2-arachidonoyl glycerol and anandamide are produced by bone cells and stimulate bone resorption in vitro
SA Ridge*, L Ford, GA Cameron, RA Ross, MJ Rogers
Bone & Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen, Aberdeen UK

12:12

OC2

Hypoxia-Inducible Factor and human osteoclasts: evidence for a positive feedback loop regulating osteoclast function
HJ Knowles*, NA Athanasou
Nuffield Department of Orthopaedic Surgery, University of Oxford, Oxford, UK

12:24

OC3

Intrauterine programming of bone-deleterious effects of a low protein diet in late adulthood on the osteogenic environment
SA Lanham*^[1], C Roberts^[1], MJ Perry^[2], C Cooper^[1], ROC Oreffo^[1]
[1]Bone and Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, Southampton, UK;^[2]Department of Anatomy, University of Bristol, UK

12:36

OC4

Differential effect of doxorubicin and zoledronic acid on intra-osseous vs extra osseous breast tumour growth in vivo
PD Ottewell*^[1], B Deux^[2], H Mönkkönen^[1], RE Coleman^[1], P Clezardin^[2], I Holen^[1]
[1]Academic Unit of Clinical Oncology, School of Medicine and Biomedical Sciences, University of Sheffield, UK;^[2]INSERM Research Unit 403, Faculté de Medicine Laënnec, 69372 Lyon Cedex 08, France

12:48

OC5

Evaluation of in vivo neovascularisation in allograft and poly D,L-Lactic Acid tissue engineered scaffolds using micro-computer tomography
BJRF Bolland, JM Kanczler*, DG Dunlop, ROC Oreffo
Bone & Joint Research Group, Developmental Origins of Health and Disease, University of Southampton, Southampton SO16 6YD, UK

Lunch and posters (odd numbers attended 13:30-14:30)

Vesicular trafficking and bone disease

Chairs: Matthew Gillespie (Melbourne, Australia) and Mike Rogers (Aberdeen, UK)

14:30

IS4

Vesicular trafficking in osteoclast biology
Fraser Coxon (Aberdeen, UK)

15:00

IS5

Diseases caused by defects in vesicular trafficking and acidification
Uwe Kornak (Berlin, Germany)

15:30

IS6

Chloride channels as a target for bone therapy
Morten Karsdal (Herlev, Denmark) 

16:00

Tea

16:30

Oral communications 2

Chairs: Bronwen Evans (Cardiff, UK) and Uwe Kornak (Berlin, Germany)

16:30

OC6

RANKL mutations are responsible for the defective osteoclast formation seen in six patients with osteoclast-poor osteopetrosis
DI Scott*^[1], FP Coxon^[1], C Sobacchi^[2], A Frattini ^[2], A Pangrazio^[2], M Guerrini^[2], L Susani^[2], A Teti^[3], C Messina^[4], G Errigo^[4], M Abinun[5], A Cant[5], N J Bishop^[6], P Grabowski^[6], RGM Bredius^[7], GMS Mancini^[8], PM Vezzoni^[2], A Villa^[2], MJ Rogers^[1] , M Helfrich^[1]
[1] Department of Medicine and Therapeutics, University of Aberdeen,UK;^[2]Institute of Biomedical Technologies, National Research Council, Segrate, Italy;^[3]Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy;^[4]Oncoematologia Pediatrica, Dipartimento di Pediatria, University of Padoa, Padoa, Italy;[5]Children's BMT Unit Newcastle General Hospital and School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK;^[6]Sheffield Children's Hospital and Academic Unit of Child Health, University of Sheffield, Sheffield, UK;^[7]Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands;^[8]Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

16:42

OC7

Downstream signalling pathways of non-canonical (RANKL-independent) pathways of osteoclast formation induced by TNF superfamily members LIGHT and APRIL
F Jones*^[1], H Knowles^[1], NA Athanasou^[2]
[1]Botnar Research Centre, Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Windmill Road, Oxford, OX3 7LD, UK;^[2]Department of Pathology, Nuffield Orthopaedic Centre, Nuffield Department of Orthopaedic Surgery, University of Oxford, Oxford, OX3 7LD, UK

16:54

OC8

Mice with a truncation mutation affecting sequestosome 1 exhibit several phenotypic features in common with Paget's disease of bone
JA Rojas*^[1], A Daroszewska^[1], M Helfrich^[2], R Layfield^[3], R van't Hof^[1], SH Ralston^[1]
[1]University of Edinburgh, Edinburgh, UK;^[2]University of Aberdeen, Aberdeen, UK;^[3]Institute of Neuroscience, University of Nottingham, Nottingham, UK

17:06

OC9

Targeting osteoclasts in rheumatoid arthritis via the alpha(v)beta(3) integrin
F Brunton*^[1], L Lee^[1], A Nissim^[2], AE Grigoriadis^[3], C Pitzalis^[1]
[1]Dept Rheumatology, KCL Guy's Hospital, London, UK;^[2]William Harvey Research Institute, QMUL, London, UK;^[3]Dept Craniofacial Dev, KCL Guy's Hospital, London, UK

17:18

OC10

Supressor of cytokine signalling-2 (SOCS-2) expression in the growth plate: modulation by pro-inflammatory cytokines.
VE MacRae*^[1], S Pells^[1], SF Ahmed^[2], C Farquharson^[1]
[1] Roslin Institute, Midlothian, UK;^[2]Royal Hospital for Sick Children, Glasgow, UK

17:30

Close

17:40

Crombie and Kings Hall residents - bus from AECC to Halls

18:30

Crombie and Kings Hall residents - bus to Town and County Hall

19:00

Civic Reception at the Town and County Hall