Wednesday 30th June

7.45

Breakfast

Mini Symposium - Tumour-induced bone disease
Chairmen: Peter Croucher/Mike Rogers

8.30

IS7
OSTEOBLASTIC BONE METASTASES
Teresa Guise (Charlottesville VA, USA)

9.00

IS8 BISPHOSPHONATES AND THE TREATMENT OF TUMOUR-INDUCED BONE DISEASE
Rob Coleman (Sheffield, UK)

9.30-10.30

Oral communications
Chairmen: Peter Croucher/Mike Rogers

9.30

OC13
NE-10790, A PHOSPHONOCARBOXYLATE ANALOGUE OF THE BISPHOSPHONATE RISEDRONATE, EXHIBITS DIRECT ANTITUMOR ACTIVITY IN VIVO
M W Lundy^[1], F H Ebetino^[1], P Clezardin^[2]. ^[1]Procter & Gamble Pharmaceuticals, OH, USA; ^[2]INSERM U403, Laennec School of Medicine, Lyon, France

9.42

OC14
(Bone and Tooth Society Scholarship) BONE MARROW ENDOTHELIAL CELLS PRODUCE OSTEOPROTEGERIN: EVIDENCE FOR A ROLE IN THE DEVELOPMENT OF MYELOMA BONE DISEASE
E De Leenheer^{[1, 2]}, K Vanderkerken^[2], G Mueller^[3], C Shipman^[3], M Bakkus^[4], B Van Camp^[2], P Croucher^[1]. ^[1]Division of Clinical Sciences, University of Sheffield Medical School, Sheffield, UK; ^[2]Hematology and Immunology, Free University Brussels, Brussels, Belgium; ^[3]Nuffield Department of Orthopaedic Surgery, University of Oxford, Oxford, UK; ^[4]Molecular Haematology Laboratory, Academic Hospital of the Free University Brussels, Brussels, Belgium

9.54

OC15
(Bone and Tooth Society Scholarship) SQSTM1 MUTATIONS IN PAGET'S DISEASE: EVIDENCE FOR A FOUNDER EFFECT ON AN ANCESTRAL CHROMOSOME BEARING THE P392L MUTATION
G J A Lucas, L J Hocking, A Daroszewska, T Cundy, GC Nicholson, J Walsh, M Hooper, S H Ralston. University of Aberdeen, UK

10.06

OC16
RANKL/OPG/RANK GENE EXPRESSION IN PERIPHERAL MONONUCLEAR CELLS FOLLOWING TREATMENT WITH ESTROGEN OR RALOXIFENE : POTENTIAL ROLE IN POST-MENOPAUSAL OSTEOPOROSIS
A Bashir^[1], Y T Mak^[1], S Sankaralingam^[1], J Cheung^[1], P T Seed^[2], N W A McGowan^[3], A E Grigoriadis^[3], I Fogelman^[4], G Hampson^[1]. ^[1]Department of Chemical Pathology, 5th Floor, North Wing, St Thomas' Hospital, London SE1 7EH, UK; ^[2]Department of Obstetrics and Gynaecology, St Thomas' Hospital, London SE1 7 EH, UK; ^[3]Department of Craniofacial Development, Kings College, Guy's Hospital, Guy's Tower Floor 27, London SE1 9RT, UK; ^[4]Osteoporosis Screening and Research Unit, Guy's Hospital, London SE1 9RT, UK

10.18

OC17
NORMAL HUMAN OSTEOCLASTS ARE ACTIVATED BY ACIDOSIS
A Brandao-Burch, T R Arnett..Department of Anatomy & Developmental Biology, University College London, London WC1E 6BT, UK

10.30-11.30

Poster viewing / coffee

11.30-12.35

Poster discussion
Chairmen: Sharyn Bord/Richard Oreffo

11.30

P1
TNF-ALPHA RECEPTOR 1 CONTROLS ENDOCHONDRAL BONE FORMATION IN ADULT MICE
I K Lukic^[1], D Grcevic^[2], N Kovacic^[1], V Katavic^[1], A Marusic^[1]. ^[1]Department of Anatomy, Zagreb University School of Medicine, Zagreb, Croatia; ^[2]Department of Physiology and Immunology, Zagreb University School of Medicine, Zagreb, Croatia

11.35

P2
DENTIN MATRIX PROTEIN-1 AND BONE DEVELOPMENT
G Li^[1], M Mushipe^[1], H Rio^[2], S Zhang^[2], L Bonewald^[2] and J Q Feng^[2]. ^[1]The Department of Orthopaedic Surgery, Queen's University Belfast, Belfast, UK. ^[2]Oral Biology, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA.

11.40

P3
COMBINED TREATMENTS OF BREAST CANCER CELLS USING BISPHOSPHONATES AND DOXORUBICIN
H L Neville-Webbe, C A Evans, R E Coleman, I Holen. Clinical Oncology, Genomic Medicine, University of Sheffield, UK

11.45

P4
ARE EPIGENETIC CHANGES IN DNA METHYLATIONS A SIGNIFICANT FACTOR IN THE ALTERED GENE EXPRESSION OF OSTEOARTHRITIC CHONDROCYTES?
S Inglis, R O C Oreffo, K A Partridge, N M P Clarke and H I Roach.Bone & Joint Research Group, University of Southampton, CF86, General Hospital, Southampton SO51 6BY, UK

11.50

P5
NE10790, A PHOSPHONOCARBOXYLATE ANALOGUE OF RISEDRONATE, INDUCES HUMAN MYELOMA CELL APOPTOSIS IN VITRO
A J Roelofs^[1], R G G Russell^[1], F H Ebetino^[2], C M Shipman^[1]. ^[1]University of Oxford, Oxford, UK; ^[2]Procter & Gamble Pharmaceuticals, Cincinnati, Ohio, USA

11.55

P6
GROUP III METABOTROPIC GLUTAMATE RECEPTORS ARE EXPRESSED IN BONE MARROW STROMAL CELLS AND ARE NEGATIVELY COUPLED TO NITRIC OXIDE SYNTHASE
M A Foreman^[1], Y Gu^[2], S J Publicover^[1]. ^[1]University of Birmingham, Birmingham, UK; ^[2]University of Cambridge, Cambridge, UK

12.00

P7
ROSUVASTATIN INHIBITS PROTEIN PRENYLATION AND BONE RESORPTION BY OSTEOCLASTS IN VITRO
A Hughes, M J Rogers and J C Crockett..Bone Research Group, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

12.05

P8
OSTEOCLASTIC CORTICAL EROSION OF THE FEMORAL NECK IS POSITIVELY ASSOCIATED WITH SUB-PERIOSTEAL ALKALINE PHOSPHATASE EXPRESSION IN ELDERLY FEMALE CASES OF HIP FRACTURE AND CONTROLS
J Power^[1], N Loveridge^[1], A Lyon^[1], N Rushton^[2], M Parker^[3], J Reeve^[1]. ^[1]Bone Research Group (MRC), University of Cambridge, UK; ^[2]Orthopaedic Research Unit, University of Cambridge, UK; ^[3]Peterborough District Hospital, Peterborough, UK

12.10

P9
MODIFICATIONS TO THE PHOSPHONATE GROUPS OF BISPHOSPHONATES AFFECTS THEIR POTENCY AND TARGET ENZYME SPECIFICITY
J A Rojas Navea^[1], M J Rogers^[1], F H Ebetino^[2], and F P Coxon^[1]. ^[1]Bone Research Group, Institute of Medical Sciences, University of Aberdeen AB25 2ZD, UK; ^[2]Procter & Gamble Pharmaceuticals, Cincinnati OH, USA

12.15

P10
INNATE IMMUNE RESPONSES TO HUMAN MESENCHYMAL STEM CELL IMPLANTATION IN IMMUNOCOMPROMISED MICE
Z Xia^[1,2], P Taylor^[3], S Gordon^[3], Z Cui^[2], J T Triffitt^[1]. ^[1]The Botnar Research Centre, Institute of Musculoskeletal Sciences; ^[2]The Department of Engineering Sciences; ^[3]Sir William Dunn School of Pathology, Oxford University, Oxford OX3 7LD

12.20

P11
IN VIVO BLOCKADE OF RETINOIC ACID RECEPTOR SIGNALLING INHIBITS CELL PROLIFERATION AND THE DIFFERENTIATION OF OSTEOCLASTS AND MATURATION OF CHONDROYTES IN REGENERATING DEER ANTLER
S P Allen, J S Price. Department of Veterinary Basic Sciences, The Royal Veterinary College London, NW1 0TU

12.25

P12
MYELOMA CELLS CAN PROMOTE OSTEOCLASTIC ACTIVITY RATHER THAN OSTEOCLAST RECRUITMENT IN VITRO; EVIDENCE FROM THE 5T2MM MURINE MODEL OF MYELOMA
G S Mueller^[1], K Vanderkerken^[2], R G G Russell^[1], P I Croucher^[3]. ^[1]Botnar Research Centre, Nuffield Department of Orthopaedic Surgery, University of Oxford, Oxford, UK; ^[2]Dept of Hematology and Immunology, Free University Brussels, Brussels, Belgium; ^[3]Division of Clinical Sciences, University of Sheffield School of Medicine, Sheffield, UK

12.30

P13
THE d2 SUBUNIT OF THE VACUOLAR H+ATPASE FORMS PART OF THE SPECIALIZED OSTEOCLAST AND RENAL PROTON PUMPS
A N Smith^[1], S Bord^[1], R S Al-Lamki^[1], F Jouret^[2], K J Borthwick^[1], D C Ireland^[1], O Devuyst^[2], F E Karet^[1]. ^[1]University of Cambridge, Cambridge, UK; ^[2]Universit� Catholique de Louvain Medical School, Brussels, Belgium

12.35-13.00

Awards / BATS AGM

13.00-14.00

 Lunch 

14.00-14.45

Clinical Cases
Chairmen: Trevor Stamp/Jon Tobias

14.00

C1
MOLECULAR DEFECT IN PSEUDOHYPOPARATHYROIDISM TYPE 1 B : 2 ILLUSTRATIVE CASES
G Hampson^[1], M Bastepe^[2], M P Champion^[3], M A Nasar^[4], H Jueppner^[2]. ^[1]Department of Chemical Pathology, St Thomas Hospital, London, UK; ^[2]Endocrine Unit, Wellman 5, Massachusetts General Hospital, Boston, USA; ^[3]Department of Paediatrics, Guy's Hospital, London, UK; ^[4]Department of Paediatrics, Conquest Hospital, East Sussex, UK

14.15

C2
VANISHING BONE DISEASE: POTENTIAL FOR BISPHOSPHONATE TREATMENT
R C Jeffery^[1], T Briggs^[1], J Wheelan^[2], R W Keen^[1,2]. ^[1]Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK; ^[2]University College London Hospitals, London, UK.

14.30

C3
LIMITED EVIDENCE OF RESCUE OF OSTEOCLAST-POOR OSTEOPETROSIS FOLLOWING 'SUCCESSFUL ENGRAFTMENT' BY CORD BLOOD FROM AN UNRELATED DONOR
B M Nicholls^[1], R Bredius^[2], S A Nesbitt^[1], M A Horton^[1], A M Flanagan^[1]. ^[1]Rayne Institute & Institute of Orthopaedics, University College London, London, UK; ^[2]Leiden University Centre, Leiden, Netherlands

14.45

IS9
MONITORING TREATMENT RESPONSE IN OSTEOPOROSIS
Aubrey Blumsohn (Sheffield, UK)

15.10-15.30

Coffee

15.30

Clinical Symposium - Update on treatment for bone disease
Chairman: Juliet Compston

15.30

IS10
BISPHOSPHONATES: ARE THEY ALL THE SAME?
Graham Russell (Oxford, UK)

15.30

IS11
INITIAL EXPERIENCE WITH TERIPARATIDE (FORTEO) IN THE UNITED STATES
Bob Marcus (Stanford CA, USA)

16.10

IS12
STRONTIUM RANELATE IN THE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS
Pierre Meunier (Lyons, France)

16.30

Panel discussion

17.00

End of meeting