Wednesday 30th June

7.45

Breakfast

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Mini Symposium - Tumour-induced bone disease
Chairmen: Peter Croucher/Mike Rogers

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8.30

IS7
OSTEOBLASTIC BONE METASTASES
Teresa Guise (Charlottesville VA, USA)

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9.00

IS8 BISPHOSPHONATES AND THE TREATMENT OF TUMOUR-INDUCED BONE DISEASE
Rob Coleman (Sheffield, UK)

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9.30-10.30

Oral communications
Chairmen: Peter Croucher/Mike Rogers

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9.30

OC13
NE-10790, A PHOSPHONOCARBOXYLATE ANALOGUE OF THE BISPHOSPHONATE RISEDRONATE, EXHIBITS DIRECT ANTITUMOR ACTIVITY IN VIVO
M W Lundy^[1], F H Ebetino^[1], P Clezardin^[2]. ^[1]Procter & Gamble Pharmaceuticals, OH, USA; ^[2]INSERM U403, Laennec School of Medicine, Lyon, France

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9.42

OC14
(Bone and Tooth Society Scholarship) BONE MARROW ENDOTHELIAL CELLS PRODUCE OSTEOPROTEGERIN: EVIDENCE FOR A ROLE IN THE DEVELOPMENT OF MYELOMA BONE DISEASE
E De Leenheer^{[1, 2]}, K Vanderkerken^[2], G Mueller^[3], C Shipman^[3], M Bakkus^[4], B Van Camp^[2], P Croucher^[1]. ^[1]Division of Clinical Sciences, University of Sheffield Medical School, Sheffield, UK; ^[2]Hematology and Immunology, Free University Brussels, Brussels, Belgium; ^[3]Nuffield Department of Orthopaedic Surgery, University of Oxford, Oxford, UK; ^[4]Molecular Haematology Laboratory, Academic Hospital of the Free University Brussels, Brussels, Belgium

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9.54

OC15
(Bone and Tooth Society Scholarship) SQSTM1 MUTATIONS IN PAGET'S DISEASE: EVIDENCE FOR A FOUNDER EFFECT ON AN ANCESTRAL CHROMOSOME BEARING THE P392L MUTATION
G J A Lucas, L J Hocking, A Daroszewska, T Cundy, GC Nicholson, J Walsh, M Hooper, S H Ralston. University of Aberdeen, UK

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10.06

OC16
RANKL/OPG/RANK GENE EXPRESSION IN PERIPHERAL MONONUCLEAR CELLS FOLLOWING TREATMENT WITH ESTROGEN OR RALOXIFENE : POTENTIAL ROLE IN POST-MENOPAUSAL OSTEOPOROSIS
A Bashir^[1], Y T Mak^[1], S Sankaralingam^[1], J Cheung^[1], P T Seed^[2], N W A McGowan^[3], A E Grigoriadis^[3], I Fogelman^[4], G Hampson^[1]. ^[1]Department of Chemical Pathology, 5th Floor, North Wing, St Thomas' Hospital, London SE1 7EH, UK; ^[2]Department of Obstetrics and Gynaecology, St Thomas' Hospital, London SE1 7 EH, UK; ^[3]Department of Craniofacial Development, Kings College, Guy's Hospital, Guy's Tower Floor 27, London SE1 9RT, UK; ^[4]Osteoporosis Screening and Research Unit, Guy's Hospital, London SE1 9RT, UK

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10.18

OC17
NORMAL HUMAN OSTEOCLASTS ARE ACTIVATED BY ACIDOSIS
A Brandao-Burch, T R Arnett..Department of Anatomy & Developmental Biology, University College London, London WC1E 6BT, UK

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10.30-11.30

Poster viewing / coffee

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11.30-12.35

Poster discussion
Chairmen: Sharyn Bord/Richard Oreffo

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11.30

P1
TNF-ALPHA RECEPTOR 1 CONTROLS ENDOCHONDRAL BONE FORMATION IN ADULT MICE
I K Lukic^[1], D Grcevic^[2], N Kovacic^[1], V Katavic^[1], A Marusic^[1]. ^[1]Department of Anatomy, Zagreb University School of Medicine, Zagreb, Croatia; ^[2]Department of Physiology and Immunology, Zagreb University School of Medicine, Zagreb, Croatia

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11.35

P2
DENTIN MATRIX PROTEIN-1 AND BONE DEVELOPMENT
G Li^[1], M Mushipe^[1], H Rio^[2], S Zhang^[2], L Bonewald^[2] and J Q Feng^[2]. ^[1]The Department of Orthopaedic Surgery, Queen's University Belfast, Belfast, UK. ^[2]Oral Biology, School of Dentistry, University of Missouri-Kansas City, Kansas City, MO, USA.

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11.40

P3
COMBINED TREATMENTS OF BREAST CANCER CELLS USING BISPHOSPHONATES AND DOXORUBICIN
H L Neville-Webbe, C A Evans, R E Coleman, I Holen. Clinical Oncology, Genomic Medicine, University of Sheffield, UK

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11.45

P4
ARE EPIGENETIC CHANGES IN DNA METHYLATIONS A SIGNIFICANT FACTOR IN THE ALTERED GENE EXPRESSION OF OSTEOARTHRITIC CHONDROCYTES?
S Inglis, R O C Oreffo, K A Partridge, N M P Clarke and H I Roach.Bone & Joint Research Group, University of Southampton, CF86, General Hospital, Southampton SO51 6BY, UK

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11.50

P5
NE10790, A PHOSPHONOCARBOXYLATE ANALOGUE OF RISEDRONATE, INDUCES HUMAN MYELOMA CELL APOPTOSIS IN VITRO
A J Roelofs^[1], R G G Russell^[1], F H Ebetino^[2], C M Shipman^[1]. ^[1]University of Oxford, Oxford, UK; ^[2]Procter & Gamble Pharmaceuticals, Cincinnati, Ohio, USA

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11.55

P6
GROUP III METABOTROPIC GLUTAMATE RECEPTORS ARE EXPRESSED IN BONE MARROW STROMAL CELLS AND ARE NEGATIVELY COUPLED TO NITRIC OXIDE SYNTHASE
M A Foreman^[1], Y Gu^[2], S J Publicover^[1]. ^[1]University of Birmingham, Birmingham, UK; ^[2]University of Cambridge, Cambridge, UK

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12.00

P7
ROSUVASTATIN INHIBITS PROTEIN PRENYLATION AND BONE RESORPTION BY OSTEOCLASTS IN VITRO
A Hughes, M J Rogers and J C Crockett..Bone Research Group, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

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12.05

P8
OSTEOCLASTIC CORTICAL EROSION OF THE FEMORAL NECK IS POSITIVELY ASSOCIATED WITH SUB-PERIOSTEAL ALKALINE PHOSPHATASE EXPRESSION IN ELDERLY FEMALE CASES OF HIP FRACTURE AND CONTROLS
J Power^[1], N Loveridge^[1], A Lyon^[1], N Rushton^[2], M Parker^[3], J Reeve^[1]. ^[1]Bone Research Group (MRC), University of Cambridge, UK; ^[2]Orthopaedic Research Unit, University of Cambridge, UK; ^[3]Peterborough District Hospital, Peterborough, UK

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12.10

P9
MODIFICATIONS TO THE PHOSPHONATE GROUPS OF BISPHOSPHONATES AFFECTS THEIR POTENCY AND TARGET ENZYME SPECIFICITY
J A Rojas Navea^[1], M J Rogers^[1], F H Ebetino^[2], and F P Coxon^[1]. ^[1]Bone Research Group, Institute of Medical Sciences, University of Aberdeen AB25 2ZD, UK; ^[2]Procter & Gamble Pharmaceuticals, Cincinnati OH, USA

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12.15

P10
INNATE IMMUNE RESPONSES TO HUMAN MESENCHYMAL STEM CELL IMPLANTATION IN IMMUNOCOMPROMISED MICE
Z Xia^[1,2], P Taylor^[3], S Gordon^[3], Z Cui^[2], J T Triffitt^[1]. ^[1]The Botnar Research Centre, Institute of Musculoskeletal Sciences; ^[2]The Department of Engineering Sciences; ^[3]Sir William Dunn School of Pathology, Oxford University, Oxford OX3 7LD

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12.20

P11
IN VIVO BLOCKADE OF RETINOIC ACID RECEPTOR SIGNALLING INHIBITS CELL PROLIFERATION AND THE DIFFERENTIATION OF OSTEOCLASTS AND MATURATION OF CHONDROYTES IN REGENERATING DEER ANTLER
S P Allen, J S Price. Department of Veterinary Basic Sciences, The Royal Veterinary College London, NW1 0TU

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12.25

P12
MYELOMA CELLS CAN PROMOTE OSTEOCLASTIC ACTIVITY RATHER THAN OSTEOCLAST RECRUITMENT IN VITRO; EVIDENCE FROM THE 5T2MM MURINE MODEL OF MYELOMA
G S Mueller^[1], K Vanderkerken^[2], R G G Russell^[1], P I Croucher^[3]. ^[1]Botnar Research Centre, Nuffield Department of Orthopaedic Surgery, University of Oxford, Oxford, UK; ^[2]Dept of Hematology and Immunology, Free University Brussels, Brussels, Belgium; ^[3]Division of Clinical Sciences, University of Sheffield School of Medicine, Sheffield, UK

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12.30

P13
THE d2 SUBUNIT OF THE VACUOLAR H+ATPASE FORMS PART OF THE SPECIALIZED OSTEOCLAST AND RENAL PROTON PUMPS
A N Smith^[1], S Bord^[1], R S Al-Lamki^[1], F Jouret^[2], K J Borthwick^[1], D C Ireland^[1], O Devuyst^[2], F E Karet^[1]. ^[1]University of Cambridge, Cambridge, UK; ^[2]Universit� Catholique de Louvain Medical School, Brussels, Belgium

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12.35-13.00

Awards / BATS AGM

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13.00-14.00

�Lunch�

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14.00-14.45

Clinical Cases
Chairmen: Trevor Stamp/Jon Tobias

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14.00

C1
MOLECULAR DEFECT IN PSEUDOHYPOPARATHYROIDISM TYPE 1 B : 2 ILLUSTRATIVE CASES
G Hampson^[1], M Bastepe^[2], M P Champion^[3], M A Nasar^[4], H Jueppner^[2]. ^[1]Department of Chemical Pathology, St Thomas Hospital, London, UK; ^[2]Endocrine Unit, Wellman 5, Massachusetts General Hospital, Boston, USA; ^[3]Department of Paediatrics, Guy's Hospital, London, UK; ^[4]Department of Paediatrics, Conquest Hospital, East Sussex, UK

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14.15

C2
VANISHING BONE DISEASE: POTENTIAL FOR BISPHOSPHONATE TREATMENT
R C Jeffery^[1], T Briggs^[1], J Wheelan^[2], R W Keen^[1,2]. ^[1]Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK; ^[2]University College London Hospitals, London, UK.

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14.30

C3
LIMITED EVIDENCE OF RESCUE OF OSTEOCLAST-POOR OSTEOPETROSIS FOLLOWING 'SUCCESSFUL ENGRAFTMENT' BY CORD BLOOD FROM AN UNRELATED DONOR
B M Nicholls^[1], R Bredius^[2], S A Nesbitt^[1], M A Horton^[1], A M Flanagan^[1]. ^[1]Rayne Institute & Institute of Orthopaedics, University College London, London, UK; ^[2]Leiden University Centre, Leiden, Netherlands

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14.45

IS9
MONITORING TREATMENT RESPONSE IN OSTEOPOROSIS
Aubrey Blumsohn (Sheffield, UK)

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15.10-15.30

Coffee

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15.30

Clinical Symposium - Update on treatment for bone disease
Chairman: Juliet Compston

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15.30

IS10
BISPHOSPHONATES: ARE THEY ALL THE SAME?
Graham Russell (Oxford, UK)

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15.30

IS11
INITIAL EXPERIENCE WITH TERIPARATIDE (FORTEO) IN THE UNITED STATES
Bob Marcus (Stanford CA, USA)

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16.10

IS12
STRONTIUM RANELATE IN THE TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS
Pierre Meunier (Lyons, France)

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16.30

Panel discussion

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17.00

End of meeting